Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.0K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.7K
3.7K
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

18.7K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
18.7K
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

7.7K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.7K
Small interfering RNAs (siRNA)02:30

Small interfering RNAs (siRNA)

4.7K
4.7K
Deformation in a Circular Shaft01:10

Deformation in a Circular Shaft

933
One of the distinctive characteristics of circular shafts is their ability to maintain their cross-sectional integrity under torsion. In other words, each cross-section continues to exist as a flat, unaltered entity, simply rotating like a solid, rigid slab. To understand the distribution of shearing stress within such a shaft, consider a cylindrical section inside this circular shaft. This section has a length of L and a radius of R, with one end fixed. The radius of the cylindrical section is...
933

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel deep intronic variants in <i>NTRK1</i> underlying congenital insensitivity to pain with anhidrosis.

Frontiers in genetics·2026
Same author

NEP89: universal neuroevolution potential for inorganic and organic materials across 89 elements.

Nature computational science·2026
Same author

Altered GABA and secondary bile acids in Guillain-Barré syndrome: association with gut dysbiosis.

Frontiers in immunology·2026
Same author

HAAO‑derived quinolinic acid fuels FDPS‑dependent AR signaling and sensitizes prostate cancer to combination therapy.

Cell death discovery·2026
Same author

Video-based gait analysis for clinical monitoring of genotype-specific functional patterns in osteogenesis imperfecta.

BMC musculoskeletal disorders·2026
Same author

Embedding Kolb's experiential learning cycle in biotechnology education: a scientific experience before learning model.

BMC medical education·2026

Related Experiment Video

Updated: Feb 13, 2026

Use of Alu Element Containing Minigenes to Analyze Circular RNAs
13:10

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Published on: March 10, 2020

7.8K

Circular RNAs and hereditary bone diseases.

Naixiang Zhai1,2, Yanqin Lu1,2, Yanzhou Wang3

  • 1Key Laboratory for Biotech-Drugs Ministry of Health, Key Laboratory for Rare & Uncommon Diseases of Shandong Province, Shandong Medicinal Biotechnology Centre, Shandong Academy of Medical Sciences, Ji'nan, China.

Intractable & Rare Diseases Research
|March 20, 2018
PubMed
Summary

Circular RNAs (circRNAs), stable molecules involved in gene regulation, show promise as biomarkers for rare hereditary bone diseases due to their tissue-specific expression and roles in bone remodeling.

Keywords:
Circular RNAbiogenesishereditary bone diseasesosteoblastosteoclast

More Related Videos

Quantification of Circular RNAs Using Digital Droplet PCR
08:39

Quantification of Circular RNAs Using Digital Droplet PCR

Published on: September 16, 2022

4.1K
Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.8K

Related Experiment Videos

Last Updated: Feb 13, 2026

Use of Alu Element Containing Minigenes to Analyze Circular RNAs
13:10

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Published on: March 10, 2020

7.8K
Quantification of Circular RNAs Using Digital Droplet PCR
08:39

Quantification of Circular RNAs Using Digital Droplet PCR

Published on: September 16, 2022

4.1K
Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.8K

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Circular RNAs (circRNAs) are non-linear RNA molecules with a covalent closed-loop structure.
  • They exhibit high stability, nuclease resistance, and species/developmental stage-specific expression.
  • circRNAs regulate gene transcription, post-transcriptional expression, miRNA interactions, and protein coding.

Purpose of the Study:

  • To review the characteristics of circRNAs.
  • To explore the recent research on the role of circRNAs in rare hereditary bone diseases.
  • To highlight circRNAs as potential biomarkers for disease prognosis.

Main Methods:

  • Literature review of existing studies on circRNAs and genetic bone disorders.
  • Analysis of circRNA characteristics, including stability and expression patterns.
  • Examination of circRNA involvement in bone remodeling and signaling pathways.

Main Results:

  • circRNAs participate in bone remodeling via signaling pathways and the circRNA-miRNA-mRNA axis.
  • Their stability and specific expression make them potential biomarkers for diseases and prognosis.
  • Research on circRNAs in rare hereditary bone disorders is currently limited.

Conclusions:

  • circRNAs possess unique properties making them valuable for understanding and diagnosing genetic bone disorders.
  • Further research is needed to fully elucidate the incidence and function of circRNAs in these conditions.
  • circRNAs represent a promising area for biomarker discovery in rare hereditary bone diseases.