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Use of calcimimetics in children with normal kidney function
Judith Sebestyen VanSickle1, Tarak Srivastava1,2, Uri S Alon3
1Bone and Mineral Disorders Clinic, Division of Nephrology, Children's Mercy Hospital, University of Missouri at Kansas City, 2401Gillham Road, Kansas City, MO, 64108, USA.
Pediatric Nephrology (Berlin, Germany)
|March 20, 2018
Summary
Calcimimetics, which modulate the calcium-sensing receptor (CaSR), can treat children with bone disorders. These drugs lower parathyroid hormone (PTH) levels, benefiting skeletal health in patients with normal kidney function.
Area of Science:
- Endocrinology
- Nephrology
- Skeletal Pathophysiology
Background:
- The calcium-sensing receptor (CaSR) is crucial for calcium homeostasis, regulating parathyroid hormone (PTH) and calcium excretion.
- Calcimimetics allosterically modulate CaSR, mimicking hypercalcemia to suppress PTH and increase calciuria.
Purpose of the Study:
- To review the role of CaSR and calcimimetics in calcium homeostasis.
- To explore the application of calcimimetics in children with normal kidney function and bone disorders where PTH suppression is beneficial.
Main Methods:
- Literature review of CaSR function and calcimimetic action.
- Discussion of clinical applications in pediatric bone and mineral disorders.
Main Results:
- Calcimimetics are primarily used for secondary hyperparathyroidism in renal failure.
- Successful application of calcimimetics demonstrated in children with bone disorders and normal kidney function.
- Elevated PTH detrimentally affects skeletal pathophysiology in these conditions.
Conclusions:
- Calcimimetics offer a therapeutic strategy for children with normal kidney function and bone disorders characterized by detrimental PTH elevation.
- Targeting CaSR with calcimimetics can improve skeletal health by suppressing PTH.
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