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Fatigue following Paediatric Acquired Brain Injury and its Impact on Functional Outcomes: A Systematic Review

Jake Wilkinson1,2, Nohely Lee Marmol1,3, Celia Godfrey1

  • 1Murdoch Children's Research Institute, Flemington Road, Parkville, VIC, 3052, Australia.

Neuropsychology Review
|March 20, 2018
PubMed

Insights

Childhood acquired brain injury (ABI) frequently causes fatigue, impacting academics and social-emotional well-being. More research is needed to understand fatigue trajectories and effective management strategies for pediatric patients.

Area of Science:

  • Neuroscience
  • Pediatrics
  • Rehabilitation Medicine

Background:

  • Fatigue is a common, yet under-researched, sequela of childhood acquired brain injury (ABI).
  • The occurrence, duration, and functional impact of fatigue in pediatric ABI populations remain uncertain.
  • Existing research lacks a comprehensive summary focusing specifically on fatigue in this demographic.

Purpose of the Study:

  • To systematically review and synthesize existing research on fatigue following pediatric acquired brain injury (ABI).
  • To consolidate findings on the prevalence, characteristics, and impact of fatigue in children with ABI.
  • To identify potential areas for future research and management strategies.

Main Methods:

  • A systematic literature search was conducted across PsycInfo, Medline, and CINAHL databases.
  • Inclusion and exclusion criteria were applied to identify relevant studies focusing on pediatric ABI and fatigue.
  • Nine papers met the criteria, categorized by injury type: traumatic brain injury (TBI), meningitis, brain tumors, and mixed ABI.

Main Results:

  • Fatigue is a significant issue for a substantial proportion of children with ABI, irrespective of the injury cause.
  • Fatigue was associated with negative outcomes, including poor academic performance, reduced physical activity, and social-emotional difficulties.
  • More severe injuries correlated with higher fatigue levels and poorer overall outcomes.

Conclusions:

  • Fatigue is a prevalent and impactful problem in children with acquired brain injuries.
  • Severity of injury is linked to increased fatigue and worse functional outcomes.
  • Further research is essential to understand fatigue trajectories and establish evidence-based management guidelines for pediatric ABI survivors.

Keywords:
Brain injuryChildrenFatigueFunctional outcomesReview

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