[Frostbite animal model preparation specification(draft)].

Area of Science:

• Biomedical research
• Pathology
• Animal modeling

Background:

• Frostbite is a prevalent winter injury affecting peripheral circulation areas like the face, ears, hands, and feet.
• Key symptoms include skin pallor, coldness, pain, numbness, and potentially severe erosions or ulcers.
• Current frostbite models primarily rely on Western medicine indicators.

Purpose of the Study:

• To develop standardized specifications for preparing frostbite animal models.
• To integrate traditional Chinese medicine (TCM) clinical symptoms with Western medicine assessments.
• To enhance the pathological relevance of frostbite animal models through comprehensive analysis.

Main Methods:

• Analysis of clinical frostbite symptoms from both TCM and Western medicine perspectives.
• Review of extensive experimental studies on existing frostbite animal models.
• Formulation of a draft specification for animal model preparation based on integrated findings.

Main Results:

• A draft specification for preparing frostbite animal models has been formulated.
• The specifications incorporate a broader range of clinical manifestations and pathological indicators.
• This approach aims to create more comprehensive and relevant animal models for frostbite research.

Conclusions:

• Standardized frostbite animal models are crucial for advancing research.
• Integrating TCM and Western medicine approaches offers a more holistic view of frostbite pathology.
• The developed specifications provide a foundation for reproducible and accurate frostbite modeling.