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Related Concept Videos

Asthma-I: Introduction01:29

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-III: Symptoms and Complications01:24

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
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Asthma-IV: Diagnostic and Management01:30

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Asthma-IV: Nursing Management01:30

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The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
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A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
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Asthma associated to rhinitis.

C Incorvaia1, S Masieri2, C Cavaliere3

  • 1Cardiac/Pulmonary Rehabilitation, ASST Pini/CTO, Milan, Italy.

Journal of Biological Regulators and Homeostatic Agents
|March 20, 2018
PubMed
Summary
This summary is machine-generated.

Allergic rhinitis (AR) and asthma are linked through a multifactorial "united airway disease" mechanism. Nasal inflammation, particularly involving eosinophils, contributes to asthma severity and poorer outcomes.

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Area of Science:

  • Immunology
  • Allergy
  • Respiratory Medicine

Background:

  • Epidemiological and clinical data demonstrate a strong association between allergic rhinitis (AR) and asthma.
  • The concept of "united airway disease" highlights the interconnectedness of the upper and lower airways.
  • Initial hypotheses focused on nasal dysfunction, naso-bronchial reflexes, and allergic inflammation spread.

Purpose of the Study:

  • To elucidate the multifactorial mechanisms linking allergic rhinitis and asthma.
  • To investigate the immunological responses involved in the nasal-bronchial connection.
  • To understand the impact of comorbid sinusitis on asthma outcomes.

Main Methods:

  • Utilizing a nasal challenge model to study immunological responses.
  • Assessing the expression of adhesion molecules (ICAM-1, VCAM-1, E-selectin) and cytokines (IL-13).
  • Evaluating clinical outcomes in patients with asthma and comorbid AR/sinusitis.

Main Results:

  • Nasal challenge induced increased expression of adhesion molecules and IL-13.
  • Elevated eosinophil counts in blood and bronchial hyper-responsiveness were observed.
  • Concomitant sinusitis in AR patients correlated with reduced pulmonary function, increased asthma symptoms, and poorer quality-of-life.

Conclusions:

  • The link between AR and asthma is complex and involves inflammatory cells, particularly eosinophils.
  • Nasal inflammation plays a significant role in the development and exacerbation of asthma.
  • Comorbid sinusitis significantly worsens asthma control and patient-reported outcomes.