A probe in the connection between inflammation, cognition and suicide
Ricardo Cáceda1, W Sue T Griffin2, Pedro L Delgado3
11 Department of Psychiatry, Stony Brook University, New York, USA.
Journal of Psychopharmacology (Oxford, England)
|March 20, 2018
Summary
Inflammation is not linked to immediate suicide risk but may be a trait associated with lifetime suicidal behavior. This study examined inflammation markers in depressed patients with severe suicidal ideation.
Area of Science:
- Neuroscience
- Psychiatry
- Immunology
Background:
- Elevated inflammation is associated with suicide risk, but its role in acute suicidal crises versus lifetime suicidal behavior is unclear.
- Limited research exists on the origins and effects of inflammation in suicidal patients.
Purpose of the Study:
- To investigate factors linked to inflammation and suicidal ideation severity in depressed patients experiencing acute suicidal crises.
Main Methods:
- Assessed 52 hospitalized depressed patients with severe suicidal ideation for suicidality, depression, anxiety, medical comorbidities, pain, impulsivity, verbal fluency, C-reactive protein (CRP), and interleukin-6 (IL-6).
- Utilized generalized linear models to analyze associations with CRP levels and suicidal ideation severity.
Main Results:
- CRP levels correlated positively with age, BMI, IL-6, current physical pain, and a history of suicide attempts.
- Suicidal ideation severity did not significantly correlate with CRP or IL-6.
- Suicidal ideation severity was associated with female sex, anxiety disorders, current physical pain, past suicide attempts, and delay discounting.
Conclusions:
- Increased inflammation does not appear to be associated with acute suicidal risk.
- Inflammation may represent a trait linked to the history of suicidal behavior rather than immediate crisis.
More Related Videos
13:20Online Repetitive Transcranial Magnetic Stimulation of Dorsomedial and Dorsolateral Prefrontal Cortex in Cognition Decision Making, and Cognitive Dissonance
Published on: December 5, 2025
1000
12:55A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
Published on: December 9, 2021
3.8K
Related Concept Videos
01:38Inflammation
62.4K
Overview
62.4K
01:38Cognitive Dissonance
37.5K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
37.5K
01:23Dietary Connections
62.2K
In biological systems, most metabolic pathways are interconnected. The cellular respiration processes that convert glucose to ATP—such as glycolysis, pyruvate oxidation, and the citric acid cycle—tie into those that break down other organic compounds. As a result, various foods—from apples to cheese to guacamole—end up as ATP. In addition to carbohydrates, food also contains proteins and lipids—such as cholesterol and fats. All of these organic compounds are used...
62.2K
01:11Introduction to Connective Tissues
15.3K
Connective tissues are one of the four main tissue types in humans that are extensively present in the body. They are characterized by cells embedded in an extracellular matrix (ECM) composed of a ground substance and three main types of protein fibers— collagen, elastic, and reticular fibers. The ground substance of connective tissues can range from a watery and jelly-like consistency to mineralized and hard. The wide variety of cells in the connective tissues include fibroblasts,...
15.3K
01:30Classification of Connective Tissues
16.3K
The connective tissues have different properties and functions in the human body. They are broadly categorized into proper, supporting, or fluid connective tissues.
Connective Tissue Proper
Connective tissue proper is the most abundant class of connective tissues. As its name implies, it predominantly connects different tissues in the body. Depending on the cell types, ground substance, viscosity, and fiber types in the ECM, connective tissue proper is further categorized into loose and dense....
Connective Tissue Proper
Connective tissue proper is the most abundant class of connective tissues. As its name implies, it predominantly connects different tissues in the body. Depending on the cell types, ground substance, viscosity, and fiber types in the ECM, connective tissue proper is further categorized into loose and dense....
16.3K
01:20Embryonic Connective Tissues
6.6K
During early development, the embryo forms two types of connective tissues— the mesenchyme and mucoid connective tissue.
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development.
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development.
6.6K