[A CASE OF A CHILD DIAGNOSED AS HYPERSENSITIVITY REACTIONS TO NONSTEROIDAL ANTI-INFLAMMATORY DRUGS AFTER ONSET OF...

Area of Science:

• Allergy and Immunology
• Pediatric Medicine
• Gastroenterology

Background:

• Oral mite anaphylaxis (OMA), triggered by consuming mite-contaminated food, was first reported in 1993.
• While OMA is recognized globally, cases, especially in children, are infrequent in Japan.
• A potential association between mite allergy and aspirin intolerance has been noted internationally.

Observation:

• A 10-year-old boy experienced anaphylaxis, including respiratory distress, abdominal pain, and vomiting, after eating Takoyaki containing mite-contaminated flour, leading to an OMA diagnosis.
• He later exhibited eyelid swelling and coughing after ingesting loxoprofen, a non-steroidal anti-inflammatory drug, suggesting possible aspirin intolerance.
• An intradermal test for loxoprofen yielded negative results.

Findings:

• This case presents a potential link between oral mite anaphylaxis and aspirin intolerance in a pediatric patient.
• The co-occurrence of OMA and suspected aspirin intolerance in this child warrants further investigation.
• The underlying mechanisms connecting mite allergy and aspirin intolerance remain unclear.

Implications:

• This report underscores the importance of considering aspirin intolerance in children diagnosed with OMA, particularly when they exhibit adverse reactions to NSAIDs.
• Further research and case accumulation are crucial to elucidate the pathological relationship between mite allergy and aspirin intolerance.
• Understanding this connection may lead to improved diagnostic and management strategies for allergic conditions in children.