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[Neonatal systemic candidiasis].

P Lequien, J P Dubos, C Zaoui

    Presse Medicale (Paris, France : 1983)
    |May 30, 1987
    PubMed
    Summary
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    Systemic Candida infections in premature infants are linked to immature immunity, catheters, and antibiotics. 5-fluorocytosine is recommended as the primary treatment for these serious fungal infections.

    Area of Science:

    • Neonatal Medicine
    • Mycology
    • Infectious Diseases

    Context:

    • Premature infants (<33 weeks gestation, <1500g) are susceptible to systemic Candida infections.
    • Factors contributing include immature cellular immunity, prolonged intravascular catheter use, and broad-spectrum antibiotic administration.
    • Candida bloodstream infections present with non-specific septicemia signs.

    Purpose:

    • To evaluate the efficacy of 5-fluorocytosine in treating systemic Candida infections in premature neonates.
    • To establish a recommended first-line treatment protocol for neonatal candidiasis.

    Summary:

    • Six premature infants with Candida bloodstream infections were treated.
    • Five infants received 5-fluorocytosine, achieving cure.
    • One infant required amphotericin B treatment.

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    Impact:

    • 5-fluorocytosine is proposed as the preferred first-choice treatment for systemic candidiasis in premature babies.
    • A policy for Candida eradication in neonatology units is advocated.
    • This study informs clinical practice and infection control strategies in neonatal intensive care settings.