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[Hyperglycemia in the initial phase of cerebral vascular complication. Index of bad prognosis]
Insights
Hyperglycemia, or high blood sugar, is a significant indicator of poor outcomes in acute stroke patients. Elevated glucose levels correlate with increased mortality and severity of brain damage.
Area of Science:
- Neurology
- Endocrinology
Context:
- Acute stroke management and prognosis.
- Evaluation of short-term outcomes in stroke patients.
Purpose:
- To assess the prognostic value of hyperglycemia in acute stroke.
- To correlate blood glucose levels with stroke severity and mortality.
Summary:
- A study of 188 acute hemiplegia patients revealed higher mortality in those with hyperglycemia (blood glucose > 2 g/L).
- Elevated glucose levels correlated with initial consciousness disturbances, hemiplegia severity, and CT-confirmed brain lesions (hemorrhage or infarct with edema).
- Hyperglycemia in acute stroke is linked to the extent of cerebral damage and serves as a sensitive indicator of poor prognosis.
Impact:
- Hyperglycemia is identified as a critical prognostic factor in acute stroke, comparable in sensitivity to consciousness disturbances or severe brain lesions.
- Findings emphasize the importance of monitoring blood glucose in acute stroke patients for risk stratification.
- This research contributes to understanding the relationship between metabolic status and neurological outcomes in stroke.
Abstract:
The short-term prognostic value of hyperglycemia in acute stroke has been evaluated from the results of the first year of activity of the Stroke Registration unit in Dijon. In 188 patients admitted to hospital for acute hemiplegia blood glucose levels were measured on admission and daily for 7 days thereafter, and a CT scan was performed within a fortnight. Mortality was significantly higher in hyperglycemic patients (more than 2 g of glucose per litre) than in normoglycemic patients. In hyperglycemic patients the increase in blood glucose level was correlated with the initial disturbances of consciousness, the severity of hemiplegia and the presence at CT of an haemorrhage or an infarct with oedematous reaction. Thus, hyperglycemia in acute stroke is related to the severity of the cerebral damage. As a factor of bad prognosis, it is as sensitive as disturbances of consciousness or severe brain lesions at CT.