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Related Experiment Video

Updated: Feb 13, 2026

A New Method for Inducing a Depression-Like Behavior in Rats

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

A New Method for Inducing a Depression-Like Behavior in Rats.

Vladimir Zeldetz¹, Dmitry Natanel², Matthew Boyko³

¹Department of Emergent Medicine, Soroka University Medical Center, Ben-Gurion University of the Negev.

Journal of Visualized Experiments : Jove

|March 20, 2018

Summary

Researchers developed the first animal model for contagious depression. Healthy rats exposed to depressed rats exhibited depressive behaviors, establishing a new paradigm for studying this phenomenon.

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Area of Science:

Neuroscience
Animal Behavior
Psychiatry

Background:

Contagious depression lacks recognition and established study models.
Understanding its mechanisms, prevention, and treatment requires an appropriate research framework.

Purpose of the Study:

To establish the first animal model for contagious depression.
To investigate the transmission of depressive behaviors between rats.

Main Methods:

Depression was induced in rats using chronic unpredictable stress (CUS).
CUS-exposed rats were cohabited with naïve rats for five weeks.
Behavioral tests, including sucrose preference, open field, and forced-swim tests, were employed.

Main Results:

Naïve rats developed depressive behaviors after cohabitation with CUS-exposed rats.
The sucrose preference test confirmed depression development and contagion.
Open field and forced-swim tests further supported the contagion findings.

Conclusions:

The study successfully created an animal model for contagious depression.
This model provides a foundation for future research into depression contagion.
Limitations include subtle behavioral differences and ethical considerations for certain tests.