TRANSMERIDIAN JET LAG AND ITS PHARMACOLOGICAL CORRECTION

Area of Science:

• Sleep Medicine
• Chronobiology
• Aerospace Medicine

Background:

• Jet lag, or desynchronosis, disrupts circadian rhythms after transmeridian travel.
• Acute jet lag negatively impacts psychophysiological functions.
• Effective prophylaxis and correction strategies are needed for air travelers.

Purpose of the Study:

• To investigate the dynamics of subjective and objective psychophysiological parameters during acute jet lag.
• To demonstrate methods for prophylaxis and correction of jet lag following transmeridian flights.
• To evaluate the efficacy of a preparatory regimen and pharmacological interventions.

Main Methods:

• Study involved 8 healthy volunteers (experimental group) and 4 controls.
• Experimental group underwent a 21-day preparatory phase with Euricoma longifolia extraction.
• Interventions during flight included Donormyl, Circadin, and artificial sleep.
• Functional diagnostics assessed autonomic, cardiovascular, and cognitive functions at baseline, post-preparation, and post-flight.

Main Results:

• The preparatory phase and pharmacological interventions demonstrated significant benefits.
• Objective and subjective measures indicated positive effects on psychophysiological parameters.
• The proposed methods were effective in correcting acute transmeridian jet lag.

Conclusions:

• Preparation for transmeridian air travel is beneficial.
• Pharmacological correction, including specific medications and sleep strategies, effectively mitigates acute jet lag.
• The study provides evidence for a successful intervention protocol for travelers experiencing jet lag.