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HUMAN'S BREATH DURING MODELED PROLONGED HYPODYNAMIA.

L N Mukhamedieva, D S Tsarkov, D S Ozerov

    Aviakosmicheskaia I Ekologicheskaia Meditsina = Aerospace and Environmental Medicine
    |March 20, 2018
    PubMed
    Summary

    Breath analysis identified acetol as a potential biomarker for tissue hypoxia in skeletal muscles and the myocardium. This finding emerged from studying healthy subjects undergoing prolonged inactivity, linking acetol levels to energy metabolism changes.

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    Area of Science:

    • Biochemistry
    • Human Physiology
    • Metabolomics

    Background:

    • Prolonged hypodynamia, or inactivity, can significantly impact human physiology.
    • Understanding biomarkers for tissue hypoxia is crucial for monitoring health during restricted activity.

    Purpose of the Study:

    • To explore the profile of volatile organic compounds (VOCs) in the breath of humans subjected to prolonged motor activity limitation.
    • To identify potential breath biomarkers for tissue hypoxia in skeletal muscles and myocardium.

    Main Methods:

    • Analysis of volatile organic compounds (VOCs) in breath samples from healthy subjects.
    • Comparison of VOC profiles with biochemical indices of energy metabolism and muscle underloading.
    • Investigating the correlation between breath acetol levels and changes in glycolytic and muscular enzymes.

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    Main Results:

    • Acetol was identified as a potential breath biomarker for tissue hypoxia in skeletal muscles and myocardium.
    • Breath acetol levels decreased during prolonged hypodynamia, correlating with altered energy metabolism and glycolysis.
    • A decline in muscular and myocardial enzyme activities during hypodynamia corresponded with a reliable decrease in breath acetol.

    Conclusions:

    • Acetol, a precursor in methylglyoxal glucose oxidation, may serve as a non-invasive biomarker for hypoxia.
    • Reduced motor activity leads to decreased breath acetol, reflecting changes in energy metabolism and muscle function.
    • Breath acetol monitoring could offer insights into physiological adaptations during prolonged inactivity.