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HUMAN'S BREATH DURING MODELED PROLONGED HYPODYNAMIA.
Aviakosmicheskaia I Ekologicheskaia Meditsina = Aerospace and Environmental Medicine
|March 20, 2018
Summary
Breath analysis identified acetol as a potential biomarker for tissue hypoxia in skeletal muscles and the myocardium. This finding emerged from studying healthy subjects undergoing prolonged inactivity, linking acetol levels to energy metabolism changes.
Area of Science:
- Biochemistry
- Human Physiology
- Metabolomics
Background:
- Prolonged hypodynamia, or inactivity, can significantly impact human physiology.
- Understanding biomarkers for tissue hypoxia is crucial for monitoring health during restricted activity.
Purpose of the Study:
- To explore the profile of volatile organic compounds (VOCs) in the breath of humans subjected to prolonged motor activity limitation.
- To identify potential breath biomarkers for tissue hypoxia in skeletal muscles and myocardium.
Main Methods:
- Analysis of volatile organic compounds (VOCs) in breath samples from healthy subjects.
- Comparison of VOC profiles with biochemical indices of energy metabolism and muscle underloading.
- Investigating the correlation between breath acetol levels and changes in glycolytic and muscular enzymes.
Main Results:
- Acetol was identified as a potential breath biomarker for tissue hypoxia in skeletal muscles and myocardium.
- Breath acetol levels decreased during prolonged hypodynamia, correlating with altered energy metabolism and glycolysis.
- A decline in muscular and myocardial enzyme activities during hypodynamia corresponded with a reliable decrease in breath acetol.
Conclusions:
- Acetol, a precursor in methylglyoxal glucose oxidation, may serve as a non-invasive biomarker for hypoxia.
- Reduced motor activity leads to decreased breath acetol, reflecting changes in energy metabolism and muscle function.
- Breath acetol monitoring could offer insights into physiological adaptations during prolonged inactivity.