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Published on: September 28, 2022
Absolute Configuration of the Cytotoxic Marine Alkaloid Monanchocidin A
Larisa K Shubina1, Tatyana N Makarieva1, Alla G Guzii1
1G. B. Elyakov Pacific Institute of Bioorganic Chemistry , Far-Eastern Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159 , Vladivostok 690022 , Russian Federation.
Abstract:
The absolute configuration of the cytotoxic guanidine alkaloid monanchocidin A with 11 stereogenic centers from the marine sponge Monanchora pulchra was determined as 5 R, 8 S, 10 S, 13 R, 14 S, 15 R, 19 R, 23 R, 37 S, 42 S, 43 R after extensive reductive degradation and conversion of the resulting alcohols to MTPA derivatives.
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