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Do depressive symptoms influence cognitive-motor coupling in multiple sclerosis?

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Area of Science:

  • Neuroscience
  • Clinical Psychology
  • Rehabilitation Medicine

Background:

  • Motor and cognitive impairments frequently co-occur in multiple sclerosis (MS).
  • The influence of depressive symptoms on the coupling between cognitive and motor functions in MS is under-researched.
  • Understanding this relationship is crucial for comprehensive MS patient care.

Purpose of the Study:

  • To investigate the role of depressive symptoms as a moderator or confounder in the cognitive-motor coupling of individuals with MS.
  • To analyze how different levels of depressive symptoms affect the relationship between motor and cognitive performance in MS.

Main Methods:

  • 131 individuals with MS were divided into elevated and non-elevated depressive symptom groups.
  • Assessed upper and lower body motor function (e.g., 6-Minute Walk Test) and cognitive functions (e.g., Symbol Digit Modalities Test).
  • Employed correlation and linear regression analyses to examine depressive symptoms' influence on cognitive-motor coupling.

Main Results:

  • Significant differences in upper and lower body motor function were observed between depressive symptom groups, but not in cognition.
  • Motor and cognitive test scores showed consistent correlations across all groups.
  • Depressive symptoms did not confound cognitive-motor coupling but minimally influenced lower body motor function.

Conclusions:

  • The strong coupling between motor function and cognitive processing speed in MS is consistent across different levels of depressive symptoms.
  • Elevated depressive symptoms appear to have a more pronounced effect on motor functioning than on cognitive functioning in individuals with MS.
  • These findings suggest targeted interventions for motor deficits in MS patients experiencing depression.