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Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
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Two factors primarily cause thromboembolic conditions.
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Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
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Positive affect significantly influences cognitive processes, including evaluation, memory, creativity, and social judgments. Compared to negative affect, positive emotional states promote more favorable interpretations of stimuli, cognitive flexibility, and heuristic processing. These effects highlight emotions' powerful role in shaping how individuals perceive, remember, and interact with the world.Influence on Evaluation and AttributionWhen individuals experience positive affect, they are...
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Cognition plays a pivotal role in shaping emotional experiences, as demonstrated by Schachter and Singer’s two-factor theory of emotion. According to this model, emotion arises from a combination of physiological arousal and cognitive interpretation. The body’s physiological response to stimuli is ambiguous and only gains emotional significance through cognitive labeling. For instance, an increased heart rate and adrenaline surge while standing near an attractive person may be...
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Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
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Related Experiment Video

Updated: Feb 13, 2026

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy
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Adjuvant radiotherapy does not affect hemostasis.

Katrine Munk Begtrup1, Johanne Andersen Hojbjerg1, Birgitte Vrou Offersen2

  • 1a Center for Hemophilia and Thrombosis, Department of Clinical Biochemistry , Aarhus University Hospital , Aarhus , Denmark.

Platelets
|March 20, 2018
PubMed
Summary

Radiotherapy does not appear to impact blood clotting (hemostasis) in early breast cancer patients undergoing adjuvant treatment. This study found no significant changes in key clotting factors or platelet function during radiation therapy.

Keywords:
Adjuvant radiotherapyearly breast cancerhemostasisplatelets

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Area of Science:

  • Oncology
  • Hematology
  • Radiotherapy

Background:

  • Cancer patients face a heightened risk of venous thromboembolic disease, a significant cause of mortality.
  • The impact of radiotherapy on hemostasis and its potential contribution to venous thromboembolic disease risk remains under-investigated.
  • Adjuvant radiotherapy is a common treatment for breast cancer, necessitating an understanding of its systemic effects.

Purpose of the Study:

  • To evaluate the effect of adjuvant radiotherapy on hemostasis in early breast cancer patients.
  • To determine if radiotherapy influences platelet function and thrombin generation.
  • To assess changes in specific hemostatic markers throughout the radiation treatment course.

Main Methods:

  • Blood samples were collected from 39 breast cancer patients before and after radiation fractions.
  • Platelet function was assessed using impedance aggregometry.
  • Thrombin generation was measured via calibrated automated thrombogram; additional markers like P-selectin, fibrinogen, and CRP were analyzed.

Main Results:

  • Platelet aggregation remained within normal limits and was unaffected by radiotherapy.
  • Key hemostatic markers including thrombin generation, P-selectin, fibrinogen, and C-reactive protein showed no substantial changes.
  • No significant alterations in hemostasis were observed during or immediately after radiotherapy sessions.

Conclusions:

  • Adjuvant radiotherapy does not appear to significantly affect hemostasis in early breast cancer patients.
  • The findings suggest that radiotherapy, at the doses studied, does not acutely increase the risk of thromboembolic events through hemostatic alterations.
  • Further research may explore long-term hemostatic effects and potential interactions with chemotherapy.