Poststatin era in atherosclerosis management: lessons from epidemiologic and genetic studies

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Laurent Yvan-Charvet1, Bertrand Cariou2

  • 1Institut National de la Santé et de la Recherche Médicale (INSERM) U1065, Université Côte d'Azur, Centre Méditerranéen de Médecine Moléculaire (C3M), Atip-Avenir, Fédération Hospitalo-Universitaire (FHU) Oncoage, Nice.

Current Opinion in Lipidology
|March 20, 2018
PubMed

Insights

Novel antiatherogenic therapies offer hope against cardiovascular diseases (CVD), the leading global cause of death. Emerging innovations aim to meet the growing therapeutic demand for these widespread conditions.

Area of Science:

  • Cardiovascular science
  • Translational medicine
  • Public health

Background:

  • Cardiovascular diseases (CVD) are the leading cause of mortality globally, causing over 17 million deaths annually.
  • Despite advancements in lipid and blood pressure management, CVD burden is projected to increase due to population aging and lifestyle factors.
  • Epidemiologic and genetic research has advanced the understanding of atherosclerosis, driving pharmaceutical innovation.

Purpose of the Study:

  • To review emerging scientific and pharmaceutical innovations in cardiovascular disease treatment.
  • To discuss the potential of novel therapies to address the global therapeutic demand for CVD.
  • To highlight recent translational successes in antiatherogenic treatments.

Main Methods:

  • Literature review of recent advancements in cardiovascular disease research.
  • Analysis of epidemiological and genetic studies informing therapeutic development.
  • Evaluation of novel lipid-lowering, glucose-lowering, and anti-inflammatory therapies.

Main Results:

  • The last decade has seen the development of novel antiatherogenic therapies.
  • Recent successes include new lipid- and glucose-lowering agents and anti-inflammatory approaches.
  • These innovations show promise in combating the increasing burden of cardiovascular diseases.

Conclusions:

  • Emerging scientific and pharmaceutical innovations hold significant promise for cardiovascular disease management.
  • Translational successes are paving the way for new treatments to meet global therapeutic needs.
  • Continued research and development are crucial to address the public health challenge posed by CVD.
Abstract

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