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Which experimental systems should we use for human microbiome science?

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Choosing the right model systems is crucial for advancing human microbiome science. Utilizing a diverse range of models, including invertebrates, enhances biomedical research and understanding of microbial communities.

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Area of Science:

  • Microbiome science
  • Animal health
  • Biomedical research

Background:

  • The health and characteristics of animals, including humans, are significantly influenced by the continuous activity of their resident microorganisms.
  • Current research in human microbiome science relies on specific model systems.

Purpose of the Study:

  • To advocate for careful selection of model systems in human microbiome research.
  • To highlight the benefits of diversifying experimental systems, including invertebrate models, for biomedical research.
  • To discuss the limitations of certain model systems for specific scientific inquiries.

Main Methods:

  • Review of current practices in microbiome research model system selection.
  • Argument for the inclusion of a wider variety of experimental systems.
  • Emphasis on the utility of invertebrate models.

Main Results:

  • A broader selection of experimental systems, particularly invertebrate models, can significantly advance biomedical research in microbiome science.
  • Model systems not amenable to genetic or experimental manipulation are suitable for a limited scope of research questions.
  • Coordinated use of multiple, diverse systems, supported by collaborative networks, optimizes microbiome science progress.

Conclusions:

  • Thoughtful selection and diversification of model systems are essential for the advancement of human microbiome science.
  • Integrating diverse experimental systems, including invertebrates, is key to unlocking new insights in biomedical research.
  • Collaboration among researchers with varied expertise is vital for leveraging multiple model systems effectively.