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Updated: Aug 27, 2026

Immunophenotyping of Orthotopic Homograft (Syngeneic) of Murine Primary KPC Pancreatic Ductal Adenocarcinoma by Flow Cytometry
Published on: October 9, 2018
Immune-based identification of cancer patients at high risk of progression
Yann-Alexandre Vano1, Florent Petitprez2, Nicolas A Giraldo3
1INSERM, UMR_S 1138, Cordeliers Research Center, Team Cancer, Immune Control and Escape, F-75006 Paris, France; University Paris Descartes Paris 5, Sorbonne Paris Cite, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France; University UPMC Paris 6, Sorbonne University, UMR_S1138-75006 Paris, France; Department of Medical Oncology, Georges Pompidou European Hospital, University Descartes Paris 5, Paris, France.
Abstract:
Tumors are highly heterogeneous structures where malignant cells interact with a large variety of cell populations, including a clinically-relevant immune component. We review and compare the most recent methods designed to analyze and quantify the composition of immune and stromal microenvironment of tumors and discuss their use in identification of patients for high risk of progression. If the impact of the various immune components on patient's relapse share common rules in most malignancies, clear cell renal cell tumors behave differently with regards to immunity. We focus on this specific pathology to show how the tumor interacts with the host's immune system and how this intricate relationship shapes the clinical outcome.
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