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Probing the Roles of Physical Forces in Early Chick Embryonic Morphogenesis
Published on: June 5, 2018
The emerging role of physical modeling in the future of structure determination
Kari Gaalswyk1, Mir Ishruna Muniyat1, Justin L MacCallum1
1Department of Chemistry, University of Calgary, Calgary, AB, Canada.
Abstract:
Biomolecular structure determination has long relied on heuristics based on physical insight; however, recent efforts to model conformational ensembles and to make sense of sparse, ambiguous, and noisy data have revealed the value of detailed, quantitative physical models in structure determination. We review these two key challenges, describe different approaches to physical modeling in structure determination, and illustrate several successes and emerging technologies enabled by physical modeling.
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