Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Group Polarization01:01

Group Polarization

39.2K
Group polarization is the strengthening of an original group attitude following the discussion of views within a group (Teger & Pruitt, 1967). That is, if a group initially favors a viewpoint, after discussion the group consensus is likely a stronger endorsement of the viewpoint. Conversely, if the group was initially opposed to a viewpoint, group discussion would likely lead to stronger opposition.
39.2K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.0K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.7K
3.7K
Molecular Shape and Polarity03:37

Molecular Shape and Polarity

76.0K
Dipole Moment of a Molecule
76.0K
Nursing Code of Ethics01:29

Nursing Code of Ethics

4.7K
The Nursing Code of Ethics sets the ethical benchmark for the profession, and guides nurses in ethical analysis and decision making at the societal, organizational, and clinical levels. The code encompasses showing compassion and respect for the patient, their families, and communities in all circumstances while committing to providing patient-centered care. In addition, the code states that nurses must advocate for the patient by defending a cause or recommendation to protect their rights,...
4.7K
Polar Coordinates01:24

Polar Coordinates

386
The polar coordinate system offers an alternative to the Cartesian coordinate system for specifying points in a plane, using a distance and an angle instead of x and y coordinates. This system is particularly advantageous in situations involving circular or rotational symmetry, such as in physics or engineering problems involving waves, oscillations, or orbital paths.Defining Polar CoordinatesIn polar coordinates, a point is represented as P(r, ��), where r is the radial distance...
386

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cisplatin resistance in an ovarian cancer model is mediated by microtubule dynamics regulator TPPP3 in synergy with tubulin code rewiring.

Cell reports·2026
Same author

Tubulin flux at spastin-induced nanodamage sites regulates microtubule rescue frequency and EB1 lifetimes.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Genotype-structure-phenotype correlations define divergent natural history in early-onset spastic paraplegia type 4.

Brain : a journal of neurology·2026
Same author

Microtubules in the axon are GDP bound but adopt a stable GTP-like expanded state.

Nature structural & molecular biology·2026
Same author

Insights into retinal disease and non-tubulin glutamylation from a RPGR-TTLL5 complex structure.

The Journal of cell biology·2026
Same author

Expression, Purification, and Microscopy-Based Assays for Engineered Recombinant Tyrosinated, Detyrosinated, and Δ2 Human Tubulin.

Cytoskeleton (Hoboken, N.J.)·2026

Related Experiment Video

Updated: Feb 13, 2026

Author Spotlight: Purifying High-Quality Tubulin to Study Protein Dynamics and Therapeutic Applications
06:30

Author Spotlight: Purifying High-Quality Tubulin to Study Protein Dynamics and Therapeutic Applications

Published on: October 11, 2024

2.3K

The tubulin code in neuronal polarity.

James H Park1, Antonina Roll-Mecak2

  • 1Cell Biology and Biophysics Unit, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA.

Current Opinion in Neurobiology
|March 20, 2018
PubMed
Summary

Neurons rely on the complex

More Related Videos

New Methods to Study Gustatory Coding
10:59

New Methods to Study Gustatory Coding

Published on: June 29, 2017

10.0K
Quantitative Microtubule Fractionation Technique to Separate Stable Microtubules, Labile Microtubules, and Free Tubulin in Mouse Tissues
07:21

Quantitative Microtubule Fractionation Technique to Separate Stable Microtubules, Labile Microtubules, and Free Tubulin in Mouse Tissues

Published on: November 17, 2023

2.7K

Related Experiment Videos

Last Updated: Feb 13, 2026

Author Spotlight: Purifying High-Quality Tubulin to Study Protein Dynamics and Therapeutic Applications
06:30

Author Spotlight: Purifying High-Quality Tubulin to Study Protein Dynamics and Therapeutic Applications

Published on: October 11, 2024

2.3K
New Methods to Study Gustatory Coding
10:59

New Methods to Study Gustatory Coding

Published on: June 29, 2017

10.0K
Quantitative Microtubule Fractionation Technique to Separate Stable Microtubules, Labile Microtubules, and Free Tubulin in Mouse Tissues
07:21

Quantitative Microtubule Fractionation Technique to Separate Stable Microtubules, Labile Microtubules, and Free Tubulin in Mouse Tissues

Published on: November 17, 2023

2.7K

Area of Science:

  • Cell Biology
  • Neuroscience
  • Molecular Biology

Background:

  • Cellular asymmetry is vital for neuron function, including growth and transport.
  • Microtubules are key structural elements and transport tracks in neurons.
  • Microtubules are composed of diverse tubulin isoforms with posttranslational modifications.

Purpose of the Study:

  • To review tubulin isoform usage and modifications in neurons.
  • To explore the 'tubulin code' hypothesis.
  • To highlight advances in understanding the tubulin code's molecular mechanisms.

Main Methods:

  • Literature review of tubulin biology in neurons.
  • Analysis of tubulin isoform diversity.
  • Examination of posttranslational modifications on tubulin.

Main Results:

  • Neurons exhibit asymmetric distribution of tubulin isoforms and modifications.
  • This diversity forms a 'tubulin code' influencing microtubule properties.
  • Recent research elucidates the molecular basis of this code.

Conclusions:

  • The 'tubulin code' is crucial for neuronal structure and function.
  • Understanding this code is key to deciphering neuronal complexity.
  • Further research continues to reveal the intricacies of tubulin regulation in neurons.