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Updated: Feb 13, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Public knowledge of chronic kidney disease evaluated using a validated questionnaire: a cross-sectional study
Pankti A Gheewala1, Gregory M Peterson2, Syed Tabish R Zaidi2
1Division of Pharmacy, School of Medicine, Faculty of Health, University of Tasmania, Hobart, TAS, Australia. Pankti.Gheewala@utas.edu.au.
Public knowledge of chronic kidney disease (CKD) in Australia is poor. Improving awareness of CKD is crucial for early detection and management of this condition.
Area of Science:
- Nephrology
- Public Health
- Health Education
Background:
- Chronic kidney disease (CKD) poses a significant health burden in Australia.
- Public awareness is a key factor influencing the uptake of CKD screening programs.
- Current data on public knowledge of CKD in Australia is limited.
Purpose of the Study:
- To develop and validate a questionnaire to assess public knowledge of CKD.
- To evaluate the level of CKD knowledge among the Australian public.
- To identify factors influencing CKD awareness.
Main Methods:
- A CKD knowledge questionnaire was developed and validated through expert review and piloting.
- Discriminant validation was conducted with pharmacy students and nephrologists.
- A cross-sectional survey of 943 Australians was performed using an online Omnibus survey with quota sampling.
- Standard multiple regression analysis identified predictors of CKD knowledge.
Main Results:
- The validated questionnaire demonstrated good internal consistency (Cronbach's alpha = 0.88).
- Public CKD knowledge scores (median 12/24) were significantly lower than those of students (19/24) and nephrologists (23/24).
- Higher education, family history of kidney failure, personal history of diabetes, and relationship status predicted higher CKD knowledge scores.
Conclusions:
- Australian public knowledge of CKD is generally poor.
- There is a significant gap in CKD understanding between the general public, students, and healthcare professionals.
- Enhancing public awareness of CKD is essential for improving early detection and management strategies in Australia.
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Cross-Sectional Research
Chronic Kidney Disease I: Introduction
Chronic Kidney Disease II: Clinical Manifestations
Chronic Kidney Disease III: Interprofessional Care
Chronic Kidney Disease IV: Nursing Management
Finding Volume Using Cross-Sectional Area

