Related Experiment Video
Updated: Feb 13, 2026
08:40
Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
Published on: August 1, 2013
18.7K
Nanoparticles for dendritic cell-based immunotherapy.
Tuan Hiep Tran1, Thi Thu Phuong Tran2, Hanh Thuy Nguyen3
1Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
International Journal of Pharmaceutics
|March 21, 2018
Summary
Nanotechnology enhances cancer immunotherapy by leveraging dendritic cell functions. This approach improves antigen presentation and therapeutic T cell responses for better anti-tumor immunity.
Area of Science:
- Immunology
- Nanotechnology
- Cancer Therapy
Background:
- Cancer remains a leading cause of mortality globally.
- Immunotherapy is a promising novel therapeutic approach for cancer.
- Immune cell crosstalk is crucial for effective anti-tumor responses.
Purpose of the Study:
- To review recent advances in nanotechnology for cancer immunotherapy.
- To highlight the role of dendritic cells in antigen presentation and T cell response.
- To explore how nanotechnology enhances dendritic cell-mediated anti-tumor immunity.
Main Methods:
- Review of current literature on nanotechnology in cancer immunotherapy.
- Focus on dendritic cell physiology and antigen presentation mechanisms.
- Analysis of nanoparticle drug delivery systems for immune modulation.
Main Results:
- Nanoparticle drug carriers improve the efficacy of cancer immunotherapies.
- Enhanced understanding of immune system interactions aids in harnessing anti-tumor immunity.
- Nanotechnology offers advanced strategies for cancer diagnosis and treatment.
Conclusions:
- Nanotechnology significantly improves the therapeutic efficacy of immunotherapies.
- Dendritic cells are key players in eliciting therapeutic T cell responses against cancer.
- Integrating nanotechnology with immunotherapy holds great promise for cancer treatment.
Related Concept Videos
01:27Tumor Immunotherapy
2.0K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.0K
01:23Neurons: The Cell Body and the Dendrites
7.3K
A typical nerve cell comprises three main components: the cell body, dendrites, and the axon. The cell body, also known as the soma or perikaryon, serves as the central biosynthetic hub housing a nucleus surrounded by cytoplasm containing organelles commonly found in most cells. Notably, Nissl bodies, clusters of the rough endoplasmic reticulum and free ribosomes responsible for protein synthesis, are distinctive features of the neuronal cell body. As neurons age, aggregates of a brown pigment...
7.3K
02:33Lewis Acids and Bases
48.5K
In 1923, G. N. Lewis proposed a generalized definition of acid-base behavior in which acids and bases are identified by their ability to accept or to donate a pair of electrons and form a coordinate covalent bond.
A coordinate covalent bond (or dative bond) occurs when one of the atoms in the bond provides both bonding electrons. For example, a coordinate covalent bond occurs when a water molecule combines with a hydrogen ion to form a hydronium ion. A coordinate covalent bond also results when...
A coordinate covalent bond (or dative bond) occurs when one of the atoms in the bond provides both bonding electrons. For example, a coordinate covalent bond occurs when a water molecule combines with a hydrogen ion to form a hydronium ion. A coordinate covalent bond also results when...
48.5K
03:21Weak Base Solutions
25.4K
Some compounds produce hydroxide ions when dissolved by chemically reacting with water molecules. In all cases, these compounds react only partially and so are classified as weak bases. These types of compounds are also abundant in nature and important commodities in various technologies. For example, global production of the weak base ammonia is typically well over 100 metric tons annually, being widely used as an agricultural fertilizer, a raw material for chemical synthesis of other...
25.4K
01:54Base Excision Repair
26.4K
One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
The first step of...
26.4K
02:54Ions as Acids and Bases
26.6K
Salts with Acidic Ions
Salts are ionic compounds composed of cations and anions, either of which may be capable of undergoing an acid or base ionization reaction with water. Aqueous salt solutions, therefore, may be acidic, basic, or neutral, depending on the relative acid-base strengths of the salt’s constituent ions. For example, dissolving the ammonium chloride in water results in its dissociation, as described by the equation:
Salts are ionic compounds composed of cations and anions, either of which may be capable of undergoing an acid or base ionization reaction with water. Aqueous salt solutions, therefore, may be acidic, basic, or neutral, depending on the relative acid-base strengths of the salt’s constituent ions. For example, dissolving the ammonium chloride in water results in its dissociation, as described by the equation:
26.6K