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Modeling Intracerebral Hemorrhage in Mice: Injection of Autologous Blood or Bacterial Collagenase
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Association Between Blood Glucose and Functional Outcome in Intracerebral Hemorrhage: A Systematic Review and

Jun Zheng1, Zhiyuan Yu1, Lu Ma1

  • 1Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

World Neurosurgery
|March 21, 2018
PubMed

Insights

High blood glucose levels are linked to poor functional outcomes in patients with intracerebral hemorrhage (ICH). This finding highlights the importance of glucose management in stroke recovery.

Area of Science:

  • Neurology
  • Endocrinology
  • Clinical Research

Background:

  • Intracerebral hemorrhage (ICH) is a severe stroke type with poor patient functional outcomes.
  • The relationship between blood glucose levels and functional outcomes in ICH patients is not well-established.
  • This study addresses the need for clarity on glucose's impact on ICH recovery.

Purpose of the Study:

  • To systematically review and meta-analyze existing literature.
  • To investigate the association between blood glucose levels and functional outcomes in ICH patients.

Main Methods:

  • A comprehensive literature search was conducted across PubMed, EMBASE, Web of Science, and Cochrane Library.
  • Included were published cohort studies examining blood glucose and functional outcome in ICH.
  • Meta-analysis utilized odds ratios (ORs) and 95% confidence intervals (CIs) for statistical analysis.

Main Results:

  • Sixteen studies were included in the meta-analysis.
  • Hyperglycemia showed a significant association with unfavorable functional outcomes (OR, 1.80; 95% CI, 1.36-2.39).
  • Increased blood glucose levels were significantly linked to poorer functional outcomes (OR, 1.05; 95% CI, 1.03-1.07).

Conclusions:

  • Elevated blood glucose levels are significantly associated with poor functional outcomes in ICH.
  • Further research with larger cohorts, varied time points, and extended follow-up is recommended.
  • Confirming this association is crucial for improving ICH patient management.
Abstract

Keywords:
Blood glucoseFunctional outcomeIntracerebral hemorrhage

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