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Related Experiment Video

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Generation of Tissue Spheroids via a 3D Printed Stamp-Like Device

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Published on: October 6, 2022

A Modular Microfluidic Device via Multimaterial 3D Printing for Emulsion Generation.

Qinglei Ji^1,2, Jia Ming Zhang², Ying Liu²

¹State Key Laboratory of Mechanics and Control of Mechanical Structures, Nanjing University of Aeronautics and Astronautics, 29 Yudao Street, Nanjing, 210016, Jiangsu, People's Republic of China.

Scientific Reports

|March 21, 2018

Summary

Multimaterial 3D printing enables pneumatic control of droplet generation in microfluidic devices. This innovation allows for the easy creation of various double emulsions with precise control over droplet number and composition.

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Published on: December 25, 2015

Area of Science:

Microfluidics
3D Printing Technology
Materials Science

Background:

Limited research exists on multimaterial 3D printing's role in droplet-microfluidics.
3D printing offers potential for novel microfluidic device fabrication.

Purpose of the Study:

To develop and demonstrate multimaterial 3D-printed devices for controlled emulsion generation.
To explore the use of pneumatic control for droplet manipulation in microfluidics.

Main Methods:

Monolithic fabrication of a 3D coaxial flexible channel device using multimaterial 3D printing.
Design and assembly of a modular microfluidic device with interchangeable function modules (Single-inlet, Pneumatic Control Unit (PCU), Dual-inlet).
Numerical and experimental validation of the flexible channel's deformation and its effect on droplet generation.

Main Results:

Demonstrated controllable deformation of the 3D printed flexible channel via air pressure for active droplet generation control.
Successfully produced double emulsions with varying numbers of inner droplets using the PCU module.
Fabricated diverse double emulsions with controlled droplet numbers and compositions using single and dual inlet modules.

Conclusions:

Multimaterial 3D printing provides an effective platform for creating advanced microfluidic devices.
Pneumatic control offers a simplified method for generating emulsions with tunable characteristics.
The modular design enhances versatility for various double emulsion applications.