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In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice
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Sequential blood meals promote Leishmania replication and reverse metacyclogenesis augmenting vector infectivity
Tiago D Serafim1, Iliano V Coutinho-Abreu1, Fabiano Oliveira1
1Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Nature Microbiology
|March 21, 2018
Summary
Subsequent blood meals in sand flies promote Leishmania parasite development. This enhances sand fly infectiousness and disease transmission, highlighting blood availability as a key factor.
Area of Science:
- Medical Entomology
- Parasitology
- Infectious Disease Transmission
Background:
- Sand flies, like other vectors, require multiple blood meals for survival.
- The impact of repeated blood feeding on pathogen development within vectors remains largely unexplored.
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