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Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy
Published on: May 27, 2020
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Increased Resting-State Cerebellar-Cerebral Functional Connectivity Underlying Chronic Tinnitus
Yuan Feng1, Yu-Chen Chen1, Han Lv2
1Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Frontiers in Aging Neuroscience
|March 21, 2018
Summary
Chronic tinnitus patients exhibit altered brain connectivity between the cerebellum and cerebral cortex. This aberrant functional connectivity is linked to tinnitus severity, suggesting a role in the condition's neuropathology.
Area of Science:
- Neuroscience
- Medical Imaging
- Auditory Neuroscience
Background:
- Chronic subjective tinnitus is a complex auditory disorder.
- Aberrant functional coupling between the cerebellum and cerebral cortex is hypothesized as a potential cause.
Purpose of the Study:
- To investigate the functional connectivity network of cerebellar regions in chronic tinnitus patients.
- To explore the relationship between cerebellar-cerebral functional connectivity and tinnitus characteristics.
Main Methods:
- Resting-state functional magnetic resonance imaging (fMRI) was employed.
- Seed-based whole-brain correlation analysis characterized cerebellar-cerebral functional connectivity.
- Connectivity measures were correlated with clinical tinnitus characteristics.
Main Results:
- Tinnitus patients showed increased functional connectivity between the cerebellum and cerebral regions (e.g., STG, PHG, IOG, precentral gyrus).
- Enhanced connectivity between the left cerebellar Lobule VIIb and right STG correlated with Tinnitus Handicap Questionnaire (THQ) scores.
- Increased connectivity between the cerebellar vermis and right STG also associated with THQ scores.
Conclusions:
- Chronic tinnitus is associated with heightened cerebellar functional connectivity to specific cerebral areas.
- These connectivity alterations are linked to distinct tinnitus characteristics.
- Disturbances in resting-state cerebellar-cerebral functional connectivity may be crucial in tinnitus neuropathology.
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