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Updated: Feb 13, 2026

Acute Myocardial Infarction in Rats
Published on: February 16, 2011
Imaging the myocardial ischemic cascade
Arthur E Stillman1, Matthijs Oudkerk2, David A Bluemke3
1Department of Radiology and Imaging Sciences, Emory University, 1365 Clifton Rd NE, Atlanta, GA, 30322, USA. aestill@emory.edu.
Insights
Non-invasive imaging is crucial for diagnosing and managing ischemic heart disease across its spectrum. Advanced imaging techniques like coronary computed tomography angiography (CCTA) and cardiac magnetic resonance (CMR) are vital for risk assessment and guiding treatment decisions.
Area of Science:
- Cardiovascular Imaging
- Ischemic Heart Disease Diagnosis
Background:
- Non-invasive imaging is increasingly vital for ischemic heart disease (IHD) management.
- Expert consensus from North American and European societies guides imaging's role.
Purpose of the Study:
- To review the current status of non-invasive imaging in IHD.
- To organize imaging's role within the myocardial ischemic cascade.
- To assess imaging's utility in surgical planning and cost-effectiveness.
Main Methods:
- Review of current non-invasive imaging modalities for IHD.
- Framework organization based on the myocardial ischemic cascade.
- Consideration of cost-effectiveness and surgical planning applications.
Main Results:
- Coronary artery calcium scoring assesses preclinical disease and risk.
- Echocardiography, CCTA, SPECT, PET, and CMR are useful for symptomatic patients.
- CCTA serves as a cost-effective gatekeeper; CMR and PET are preferred post-infarction.
Conclusions:
- Non-invasive imaging is integral to IHD diagnosis and management.
- Imaging guides surgical planning for procedures like coronary artery bypass.
- Strategic use of imaging offers cost-effective patient care.
Abstract:
Non-invasive imaging plays a growing role in the diagnosis and management of ischemic heart disease from its earliest manifestations of endothelial dysfunction to myocardial infarction along the myocardial ischemic cascade. Experts representing the North American Society for Cardiovascular Imaging and the European Society of Cardiac Radiology have worked together to organize the role of non-invasive imaging along the framework of the ischemic cascade. The current status of non-invasive imaging for ischemic heart disease is reviewed along with the role of imaging for guiding surgical planning. The issue of cost effectiveness is also considered. Preclinical disease is primarily assessed through the coronary artery calcium score and used for risk assessment. Once the patient becomes symptomatic, other imaging tests including echocardiography, CCTA, SPECT, PET and CMR may be useful. CCTA appears to be a cost-effective gatekeeper. Post infarction CMR and PET are the preferred modalities. Imaging is increasingly used for surgical planning of patients who may require coronary artery bypass.
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