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Developmental Exposures to Perfluoroalkyl Substances (PFASs): An Update of Associated Health Outcomes

Zeyan Liew1, Houman Goudarzi2,3, Youssef Oulhote4

  • 1Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), 650 Charles E. Young Dr. South, Los Angeles, CA, 90095, USA.

Current Environmental Health Reports
|March 21, 2018
PubMed

Insights

Perfluoroalkyl substances (PFASs) exposure during pregnancy and after birth may affect child growth and immune function. More research is needed on neurodevelopmental effects of these persistent pollutants.

Area of Science:

  • Environmental Health
  • Toxicology
  • Epidemiology

Background:

  • Perfluoroalkyl substances (PFASs) are persistent organic pollutants widely used since the 1950s.
  • Global human exposure to PFASs is nearly ubiquitous.
  • Animal studies indicate adverse developmental effects from prenatal PFAS exposure.

Purpose of the Study:

  • To review and summarize epidemiological evidence on prenatal and postnatal PFAS exposure effects on offspring health.
  • Focus on birth outcomes, postnatal growth, immunomodulatory effects, and neurodevelopment.
  • Discuss research challenges and future directions in PFASs-focused studies.

Main Methods:

  • Systematic review of epidemiological studies.
  • Analysis of evidence linking PFAS exposure to specific health outcomes in offspring.
  • Evaluation of methodological strengths and limitations in existing research.

Main Results:

  • Epidemiological findings suggest associations between PFAS exposure and fetal/postnatal growth and immune function.
  • Evidence indicates potential immunomodulatory effects.
  • Findings on neurodevelopmental endpoints are currently inconclusive.

Conclusions:

  • Prenatal and postnatal PFAS exposure may impact offspring growth and immune system development.
  • Further research is necessary to clarify the effects of PFASs on neurodevelopment.
  • Addressing methodological challenges is crucial for advancing PFASs health research.
Abstract

Keywords:
Developmental exposuresFetal growthImmunotoxicityNeurodevelopmentPerfluoroalkyl substances

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