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Protein C deficiency in splanchnic venous thrombosis
The American Journal of Medicine
|June 1, 1987
Summary
Patients with splanchnic venous thrombosis often show deficiencies in protein C and antithrombin III. This study suggests a cycle of thrombosis and liver damage due to reduced anticoagulant proteins.
Area of Science:
- Hematology
- Gastroenterology
- Vascular Medicine
Background:
- Splanchnic venous thrombosis (SVT) is a serious condition.
- The role of anticoagulant deficiencies in SVT pathogenesis requires further elucidation.
Purpose of the Study:
- To investigate protein C and other coagulation factor levels in patients with SVT.
- To explore the potential mechanisms linking anticoagulant deficiencies to SVT.
Main Methods:
- Assessed protein C activity and antigen levels.
- Measured free protein S antigen and antithrombin III levels.
- Analyzed the ratio of protein C to factor X.
Main Results:
- Eight consecutive SVT patients exhibited protein C deficiencies.
- A significant reduction in the protein C to factor X ratio was observed.
- Six patients had decreased antithrombin III; free protein S was mostly normal.
Conclusions:
- Consumption of protein C and antithrombin III may predispose to SVT.
- A proposed vicious cycle involves thrombosis, impaired hepatic function, and further anticoagulant depletion.
- These findings highlight the importance of assessing coagulation status in SVT.