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STK24 expression is modulated by DNA copy number/methylation in lung adenocarcinoma and predicts poor survival
Ningyu Huang1, Wenbo Lin1, Xiuyu Shi1
1State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361102, PR China.
Aim:
To explore the independent prognostic value of STK24 expression in terms of overall survival and recurrence-free survival and the potential mechanisms of its dysregulation in non-small-cell lung adenocarcinoma.
Patients & Methods:
Data were from the Cancer Genome Atlas-lung adenocarcinoma.
Results:
Increased STK24 expression was an independent prognostic indicator of unfavorable overall survival (Hazard ratio: 1.478; 95% CI: 1.149-1.901; p < 0.002) and recurrence-free survival (Hazard ratio: 1.855; 95% CI: 1.399-2.458; p < 0.001). DNA amplification was associated with significantly upregulated STK24 expression. There was a weak negative correlation between STK24 expression and its DNA methylation (Pearson's r = -0.32).
Conclusion:
Aberrant STK24 expression was an independent prognostic indicator in lung adenocarcinoma patients. Its dysregulation was associated with its DNA copy number alteration and methylation.
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