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Related Concept Videos

Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

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The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Updated: Feb 13, 2026

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
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Microtechnology applied to stem cells research and development.

Juan Pablo Acevedo1,2, Ioannis Angelopoulos1,2, Danny van Noort3,4

  • 1Laboratory of Nano-Regenerative Medicine, Faculty of Medicine, Universidad de Los Andes, Santiago, Chile.

Regenerative Medicine
|March 21, 2018
PubMed
Summary
This summary is machine-generated.

Microtechnology offers advanced tools for studying stem cell functions, including differentiation and therapeutic potential. These microdevices enable more realistic assessments, accelerating regenerative medicine translation.

Keywords:
cancerdifferentiationmicrofabricationmicrofluidicsmicrotechnologyregenerative medicinestem cellstranslational medicine

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Area of Science:

  • Biotechnology
  • Cell Biology
  • Regenerative Medicine

Background:

  • Microfabrication and microfluidics are crucial for studying cellular functions and environmental interactions.
  • Microfluidic technologies have demonstrated utility in cell isolation, selection, characterization, and migration studies.

Purpose of the Study:

  • To equip stem cell researchers with a microtechnology (mT) toolkit for complex stem cell function analysis.
  • To address limitations of traditional assays and animal models in deciphering stem cell behavior.
  • To review microdevices applicable to stem cell differentiation, niche interaction, transcriptomics, and therapeutic functions.

Main Methods:

  • Review of microtechnology (mT) instruments and microdevices.
  • Application of microdevices for investigating stem cell differentiation and niche interactions.
  • Utilizing microdevices for stem cell transcriptomics analysis.
  • Employing microdevices for assessing stem cell therapeutic functions and capturing secreted microvesicles.

Main Results:

  • Microdevices facilitate detailed investigation of stem cell differentiation and niche interactions.
  • Microtechnology enables advanced analysis of stem cell transcriptomics.
  • Microdevices are effective for evaluating stem cell therapeutic functions.
  • Microfluidic systems allow for the capture and analysis of stem cell-secreted microvesicles.

Conclusions:

  • Microtechnology provides a more realistic assessment of stem cell properties.
  • Microtechnology accelerates the translation of regenerative medicine approaches to clinical applications.
  • Microdevices offer novel avenues for understanding complex stem cell biology.