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Symptomatic atlantoaxial dislocation in Down's syndrome.

V Chaudhry, C Sturgeon, A J Gates

    Annals of Neurology
    |June 1, 1987
    PubMed
    Summary
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    Atlantoaxial dislocation can cause spinal cord compression in individuals with Down syndrome, leading to walking difficulties and quadriparesis. Early recognition and immobilization are crucial for managing this serious complication.

    Area of Science:

    • Neurology
    • Orthopedics
    • Genetics

    Background:

    • Down syndrome is associated with an increased risk of atlantoaxial instability.
    • Atlantoaxial dislocation can lead to severe neurological deficits.

    Observation:

    • Four patients with Down syndrome presented with spinal cord compression due to atlantoaxial dislocation.
    • All patients exhibited inability to walk and quadriparesis, indicating cervical myelopathy.

    Findings:

    • Atlantoaxial dislocation is a critical complication in Down syndrome that can cause spinal cord compression.
    • Neurological symptoms include loss of ambulation and quadriparesis.

    Implications:

    • Prompt recognition of symptoms like neck pain, torticollis, or gait disturbance in Down syndrome patients is vital.

    Related Experiment Videos

  • Immediate cervical immobilization and radiography are recommended for suspected cases.
  • Surgical fusion of the upper cervical vertebrae offers a therapeutic solution.