Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Flow01:29

Blood Flow

76.2K
Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
76.2K
Autoregulation of Blood Flow01:17

Autoregulation of Blood Flow

8.2K
Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
8.2K
Adhesion01:14

Adhesion

44.6K
Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow...
44.6K
Cell Adhesion in Plants01:14

Cell Adhesion in Plants

3.4K
Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose,...
3.4K
Applications of Integration to Find Blood Flow01:27

Applications of Integration to Find Blood Flow

60
Blood flow through a cylindrical blood vessel can be mathematically described using the principles of laminar flow, a regime in which fluid moves smoothly in parallel layers. In this model, the velocity of the blood is not uniform across the cross-section of the vessel; rather, it varies with the radial distance from the center. The maximum velocity occurs along the central axis, decreasing progressively toward the vessel walls, where it reaches zero due to viscous drag.Approximating Blood...
60
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

4.4K
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
4.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Validation of Gazelle Microchip Electrophoresis for Premarital Hemoglobinopathy Screening in Türkiye.

EJHaem·2026
Same author

High-Altitude Hypoxemia in Adults With Sickle Cell Disease (SCD).

American journal of hematology·2026
Same author

Fundamentals of big data and artificial intelligence in transfusion medicine.

Vox sanguinis·2026
Same author

Microfluidic capillary transit velocity as a functional measure for sickle cell disease and <i>in vitro</i>-derived red blood cells.

Lab on a chip·2026
Same author

Low Use of FDA-Approved Medications for Sickle Cell Disease in Adults.

European journal of haematology·2025
Same author

Predicting Acute Chest Syndrome in Adults with Sickle Cell Disease.

NEJM evidence·2025

Related Experiment Video

Updated: Feb 13, 2026

Introducing Shear Stress in the Study of Bacterial Adhesion
13:28

Introducing Shear Stress in the Study of Bacterial Adhesion

Published on: September 2, 2011

16.3K

Shear dependent red blood cell adhesion in microscale flow.

Erdem Kucukal1, Jane A Little2, Umut A Gurkan3

  • 1Department of Mechanical and Aerospace Engineering, Case Biomanufacturing and Microfabrication Laboratory, Case Western Reserve University, Glennan 616B, 10900 Euclid Ave., Cleveland, OH, USA. umut@case.edu.

Integrative Biology : Quantitative Biosciences From Nano to Macro
|March 21, 2018
PubMed
Summary
This summary is machine-generated.

Red blood cell (RBC) adhesion in sickle cell disease (SCD) varies with blood flow. A new microfluidic method reveals this shear-dependent adhesion heterogeneity, linking it to clinical factors in SCD patients.

More Related Videos

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry
09:12

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry

Published on: January 12, 2018

15.5K
Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells
10:10

Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells

Published on: October 27, 2009

18.7K

Related Experiment Videos

Last Updated: Feb 13, 2026

Introducing Shear Stress in the Study of Bacterial Adhesion
13:28

Introducing Shear Stress in the Study of Bacterial Adhesion

Published on: September 2, 2011

16.3K
Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry
09:12

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry

Published on: January 12, 2018

15.5K
Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells
10:10

Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells

Published on: October 27, 2009

18.7K

Area of Science:

  • Biomedical Engineering
  • Hematology
  • Microfluidics

Background:

  • Red blood cell (RBC) deformability and non-adherence are crucial for microcirculation.
  • Vaso-occlusion in sickle cell disease (SCD) stems from abnormal RBC adhesion.
  • RBC adhesiveness and deformability heterogeneity in SCD requires study under dynamic shear gradients.

Purpose of the Study:

  • To investigate shear-dependent RBC adhesion in SCD using a microfluidic system.
  • To develop a subject-specific index for assessing RBC adhesion under varying shear stress.
  • To correlate RBC adhesion patterns with clinical markers in SCD patients.

Main Methods:

  • Developed a microfluidic system simulating physiological shear gradients.
  • Functionalized microchannels with vascular endothelial proteins.
  • Measured shear-dependent RBC adhesion in 28 SCD subjects and 11 healthy controls.
  • Defined the RBC Shear Gradient Microfluidic Adhesion (SiGMA) index.

Main Results:

  • Demonstrated shear-dependent RBC adhesion heterogeneity in a microfluidic model.
  • The SiGMA index quantifies subject-specific RBC adhesion.
  • Found correlations between RBC adhesion patterns, inflammatory markers, and iron overload in SCD.

Conclusions:

  • Shear-dependent RBC adhesion is heterogeneous in SCD and linked to clinical outcomes.
  • Microfluidic analysis of RBC adhesion offers insights into SCD pathophysiology.
  • These findings may inform understanding of other microcirculatory and microvascular diseases.