Related Experiment Video
Updated: Feb 13, 2026

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
Published on: February 17, 2018
[Chronic heart failure and depression]
1Klinik für Psychosomatische Medizin und Psychotherapie, Universitätsmedizin Göttingen, Georg-August-Universität, von-Siebold-Str. 5, 37099, Göttingen, Deutschland. cherrma@gwdg.de.
Insights
Depression frequently co-occurs with heart failure, impacting quality of life. While psychotherapy shows promise, current evidence doesn't support specific antidepressant treatments for heart failure patients beyond standard care.
Area of Science:
- Cardiology
- Psychiatry
- Psychocardiology
Background:
- Depression is a common comorbidity in chronic heart failure (CHF).
- It can be both a consequence of CHF and a contributing factor to its progression and poor prognosis.
Purpose of the Study:
- Investigate the links between heart failure and depression.
- Examine psychophysiological and behavioral mechanisms involved.
- Assess depression's impact on quality of life in CHF patients and review therapies.
Main Methods:
- A narrative literature review was conducted.
Main Results:
- Psychophysiological and behavioral factors mediate the association between depression and CHF.
- Comorbid depression significantly reduces health-related quality of life.
- Exercise and cognitive behavioral therapy offer partial improvement; antidepressant efficacy is unproven in CHF.
Conclusions:
- Current guidelines suggest identifying and treating depression in CHF patients.
- No specific treatments beyond standard CHF care, lifestyle changes, and patient-centered care are strongly supported.
- Psychotherapy, particularly cognitive behavioral therapy, is recommended. Specialized psychocardiological inpatient programs are available in Germany.
Background:
Depression is a frequent comorbidity in chronic heart failure. It can be triggered by the experience of suffering from heart disease, but it can also play a causal role in accelerated development and poor prognosis of heart failure.
Objectives:
The aim of this study was to investigate the interrelationships between heart failure and depression and the psychophysiological and behavioral mechanisms involved in this association. The effects of comorbid depression on quality of life in patients with heart failure were also examined and therapeutic options reviewed.
Methods:
A narrative review of the literature was undertaken.
Results:
Several psychophysiological and behavioral mechanisms have been identified as mediators of the association between depression and heart failure and the adverse prognostic effects of this comorbidity. Comorbid depression leads to substantial reductions in health-related quality of life. These effects are only incompletely antagonized by exercise training and cognitive behavioral therapy. No specific effect of antidepressant medication has been demonstrated as yet in patients with heart failure.
Discussion:
While current guidelines recommend the identification and treatment of depressive comorbidity in patients with heart failure, the available evidence provides no convincing rationale for specific treatment recommendations beyond the guideline-based treatment of heart failure itself, lifestyle interventions and patient-centered medical care. If available, psychotherapy should be offered, ideally cognitive behavioral therapy. For patients that do not improve sufficiently under outpatient treatment, the German health care system offers dedicated psychocardiological inpatient treatment programs.
More Related Videos
07:41Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension
Published on: March 17, 2022
07:49Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
Published on: July 21, 2023
Related Concept Videos
Heart Failure II: Pathophysiology
Pathophysiology of Heart Failure
Heart Failure I: Introduction
Heart Failure VI: Adjunct Therapies
Heart Failure Drugs: Diuretics
Heart Failure V: Medical Management