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An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
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Overall and cause-specific mortality in giant cell arteritis : A meta-analysis
1Department of Rheumatology, Korea University Anam Hospital, Korea University College of Medicine, 73, Inchon-ro, 02841, Seoul, Seongbuk-gu, Korea (Republic of). lyhcgh@korea.ac.kr.
Zeitschrift Fur Rheumatologie
|March 21, 2018
Summary
Giant cell arteritis (GCA) patients do not have higher all-cause mortality rates. However, individuals with GCA face an increased risk of death from cardiovascular disease (CVD).
Area of Science:
- Rheumatology
- Epidemiology
- Cardiovascular Medicine
Background:
- Giant cell arteritis (GCA) is a large vessel vasculitis with potential systemic complications.
- Understanding the mortality profile of GCA patients is crucial for clinical management and risk stratification.
Purpose of the Study:
- To assess all-cause and cause-specific standardized mortality ratios (SMRs) in patients diagnosed with GCA.
- To compare mortality risks in GCA patients against the general population.
Main Methods:
- A systematic literature review and meta-analysis were conducted.
- Studies were identified using MEDLINE, EMBASE, Cochrane databases, and manual searches.
- All-cause, sex-specific, region-specific, and cause-specific SMRs were pooled and analyzed.
Main Results:
- The meta-analysis included 8 reports with 1972 GCA patients.
- All-cause SMR was not significantly increased in GCA patients (SMR 1.081).
- Mortality due to cardiovascular disease (CVD) was significantly increased (SMR 1.312), while cancer mortality was not (SMR 0.833).
Conclusions:
- GCA patients do not exhibit elevated all-cause mortality, irrespective of sex or region.
- There is a significant increase in mortality risk from cardiovascular disease in GCA patients.
- No increased mortality risk was observed for cancer-related deaths in GCA patients.
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