Complications during esophageal endoscopy with or without baloon dilation under general anesthesia in pediatric

Pinar Kendigelen1, Ayse C Tutuncu2, Senol Emre3

  • 1Department of Anesthesiology and Intensive Care, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.

Insights

Pediatric esophagoscopy, particularly with balloon dilation, can cause significant increases in peak inspiratory pressure (PIP), especially in younger children. Careful monitoring for cardio-respiratory complications during and after these procedures is essential.

Area of Science:

  • Pediatric Gastroenterology
  • Anesthesiology
  • Cardiopulmonary Physiology

Background:

  • Esophagoscopy in children, especially with dilation techniques, carries risks of cardio-respiratory complications.
  • Understanding these risks is crucial for patient safety during pediatric endoscopic procedures.

Purpose of the Study:

  • To identify cardio-respiratory alterations during esophagoscopy with or without balloon dilation in children under anesthesia.
  • To investigate the incidence of postoperative complications associated with these procedures.

Main Methods:

  • A prospective, observational study involving 102 procedures in 60 pediatric patients (0-16 years).
  • Patients were divided into an endoscopy-dilation group (Group ED) and an endoscopy-only group (Group E).
  • Hemodynamic and ventilatory parameters were recorded during the procedure and for two hours postoperatively.

Main Results:

  • Peak inspiratory pressure (PIP) significantly increased after endoscopy in both groups.
  • The dilation group showed a significant increase in PIP during the procedure.
  • PIP increase was negatively correlated with age, with significant increases observed in children under two years old.
  • Heart rate (HR) also significantly increased in the dilation group during the procedure.

Conclusions:

  • Esophagoscopy, with or without balloon dilation, leads to increased PIP in pediatric patients, particularly those undergoing dilation.
  • Younger children (<2 years) experience a more pronounced PIP increase.
  • Close observation and management of severe respiratory and cardiovascular complications are critical during balloon dilation under general anesthesia.
Abstract

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
277
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
334
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
246
Observational Studies01:11

Observational Studies

Observational studies are a type of analytical study where researchers observe events without any interventions. In other words, the researcher does not influence the response variable or the experiment's outcome.
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
11.1K
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
310
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
589