Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Continuing Care01:25

Continuing Care

2.0K
Continuing care describes the variety of health, personal, and social services provided over a prolonged period. The need for continuing care is increasing because people are living longer. Many people do not have families or others to care for them. Continuing care is mainly for patients who are disabled, functionally dependent, or suffering from a terminal disease. It is available within institutional settings or in homes. Examples include nursing centers or facilities, assisted living,...
2.0K
Continuity of a Function01:23

Continuity of a Function

253
A function is continuous at a point a if three conditions are met: the function is defined at a, the limit of the function as x approaches a exists, and this limit equals the function’s value. Mathematically, this is written asThis definition ensures the graph of the function does not exhibit any breaks, holes, or jumps at that point. Discontinuities occur when any of these conditions fail. A removable discontinuity exists when the two-sided limit exists but the function is either...
253
Continuity Equation01:28

Continuity Equation

3.4K
The continuity equation asserts that the mass flow rate must remain constant for a steady flow of an incompressible fluid within a confined system. This principle applies to systems where fluid passes through varying cross-sectional areas, such as nozzles, syringes, and pipes.
The mass flow rate is expressed as:
3.4K
Continuity Equation01:20

Continuity Equation

1.5K
The total amount of current flowing per unit cross-sectional area is called the current density. Hence, the current passing through a cross-sectional area can be written as the surface integral of the current density.
1.5K
Equation of Continuity01:12

Equation of Continuity

11.2K
Fluid motion is represented by either velocity vectors or streamlines. The volume of a fluid flowing past a given location through an area during a period of time is called the flow rate Q, or more precisely, the volume flow rate. Flow rate and velocity are related—for instance, a river has a greater flow rate if the velocity of the water in it is greater. However, the flow rate also depends on the size and shape of the river. The relationship between flow rate (Q) and average speed (v)...
11.2K
Properties of Continuous Functions01:29

Properties of Continuous Functions

192
Continuous functions exhibit smooth, uninterrupted behavior, and combining them through standard operations retains this continuity. If f and g are continuous at a point a, then the functions f+g, f-g, cf (where c is a constant), fg, and fg (provided g(a)a) are also continuous at a. This allows the construction of complex functions from simpler continuous parts without losing smoothness.Polynomials, which are expressions formed by sums of powers of x with constant coefficients, are continuous...
192

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erratum. Mediobasal Hypothalamic SIRT1 Is Essential for Resveratrol's Effects on Insulin Action in Rats. Diabetes 2011;60:2691-2700.

Diabetes·2017
Same author

Translational Medicine Guide transforms drug development processes: the recent Merck experience.

Drug discovery today·2016
Same author

Mediobasal hypothalamic SIRT1 is essential for resveratrol's effects on insulin action in rats.

Diabetes·2011
Same author

An audience with Luciano Rossetti. Interview by Bethan Hughes.

Nature reviews. Drug discovery·2010
Same author

Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons.

Diabetes·2009
Same author

The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis.

Molecular and cellular biology·2009

Related Experiment Video

Updated: Feb 13, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
08:38

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Published on: November 8, 2015

17.5K

Treating MS without continuous immunosuppression: an interview with Luciano Rossetti.

Luciano Rossetti1

  • 1Merck KGaA, Darmstadt, Germany.

Neurodegenerative Disease Management
|March 21, 2018
PubMed
Summary

Dr. Luciano Rossetti transformed Merck KGaA's R&D, accelerating drug discovery and development. His leadership advances scientific innovation to deliver new medicines for patients.

Keywords:
ECTRIMScladribine tabletsimmune systemimmunosuppressionmultiple sclerosis (MS)

More Related Videos

Biology of Microbial Communities - Interview
14:42

Biology of Microbial Communities - Interview

Published on: May 28, 2007

9.1K
Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

6.2K

Related Experiment Videos

Last Updated: Feb 13, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
08:38

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Published on: November 8, 2015

17.5K
Biology of Microbial Communities - Interview
14:42

Biology of Microbial Communities - Interview

Published on: May 28, 2007

9.1K
Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

6.2K

Area of Science:

  • Pharmaceutical R&D and Drug Development
  • Healthcare Innovation Strategy
  • Biopharmaceutical Industry Leadership

Background:

  • Luciano Rossetti, MD, leads global R&D strategy at Merck KGaA, Darmstadt, Germany.
  • He has extensive experience in pharmaceutical discovery and late-stage development, previously at Merck Sharp & Dohme (MSD).
  • His background includes 18 years in academia, focusing on medicine and diabetes research.

Observation:

  • Dr. Rossetti joined Merck KGaA in July 2014, driving pipeline acceleration and innovation.
  • He has been instrumental in transforming the R&D division.
  • His leadership aims to translate scientific, clinical, and regulatory excellence into patient benefit.

Findings:

  • Under his direction, key R&D programs have been expedited through the development pipeline.
  • Merck KGaA's discovery and development efforts in healthcare have seen significant advancement.
  • The R&D transformation holds potential for delivering novel therapies to patients.

Implications:

  • The strategic leadership in R&D is poised to enhance the delivery of medical advancements.
  • This transformation signifies a commitment to addressing unmet patient needs through innovation.
  • Dr. Rossetti's approach is expected to yield significant contributions to pharmaceutical science and patient care.