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Interplay between regulation by methylation and noncoding RNAs in cancers

Chun-Xiao Lu1, Xiao-Li Wu2, Guang-Yuan Zhang2

  • 1School of Pharmaceutical Sciences.

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
|March 21, 2018
PubMed

Insights

This review explores how DNA methylation and noncoding RNAs interact to drive cancer development. Understanding these epigenetic mechanisms is key for developing new cancer treatments.

Area of Science:

  • Epigenetics and Molecular Oncology
  • Cancer Biology and Therapeutics

Background:

  • Cancer remains a major global health challenge, necessitating research into its underlying mechanisms.
  • Cancer epigenetics, including DNA methylation, histone modification, and noncoding RNA regulation, plays a crucial role in cancer development and progression.

Purpose of the Study:

  • To review the intricate interplay between DNA methylation and noncoding RNAs in the context of cancer.
  • To highlight how these epigenetic factors collectively influence tumorigenesis and disease progression.

Main Methods:

  • Literature review focusing on epigenetic mechanisms in cancer.
  • Analysis of studies investigating the combined roles of DNA methylation and noncoding RNAs.

Main Results:

  • Epigenetic events, specifically DNA methylation and noncoding RNA activities, are interconnected in cancer.
  • These interactions significantly impact various stages of cancer development and progression.

Conclusions:

  • The coordinated action of DNA methylation and noncoding RNAs is critical for understanding cancer.
  • Targeting these epigenetic interactions presents a promising avenue for novel cancer therapies.

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