Related Experiment Video
Updated: Feb 13, 2026
06:44
Isolation of Small Noncoding RNAs from Human Serum
Published on: June 19, 2014
18.6K
Interplay between regulation by methylation and noncoding RNAs in cancers.
Chun-Xiao Lu1, Xiao-Li Wu2, Guang-Yuan Zhang2
1School of Pharmaceutical Sciences.
Summary
This review explores how DNA methylation and noncoding RNAs interact to drive cancer development. Understanding these epigenetic mechanisms is key for developing new cancer treatments.
Area of Science:
- Epigenetics and Molecular Oncology
- Cancer Biology and Therapeutics
Background:
- Cancer remains a major global health challenge, necessitating research into its underlying mechanisms.
- Cancer epigenetics, including DNA methylation, histone modification, and noncoding RNA regulation, plays a crucial role in cancer development and progression.
Purpose of the Study:
- To review the intricate interplay between DNA methylation and noncoding RNAs in the context of cancer.
- To highlight how these epigenetic factors collectively influence tumorigenesis and disease progression.
Main Methods:
- Literature review focusing on epigenetic mechanisms in cancer.
- Analysis of studies investigating the combined roles of DNA methylation and noncoding RNAs.
Main Results:
- Epigenetic events, specifically DNA methylation and noncoding RNA activities, are interconnected in cancer.
- These interactions significantly impact various stages of cancer development and progression.
Conclusions:
- The coordinated action of DNA methylation and noncoding RNAs is critical for understanding cancer.
- Targeting these epigenetic interactions presents a promising avenue for novel cancer therapies.
Related Concept Videos
01:46Epigenetic Regulation
33.9K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.9K
02:39lncRNA - Long Non-coding RNAs
10.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.0K
02:39lncRNA - Long Non-coding RNAs
3.7K
3.7K
02:30siRNA - Small Interfering RNAs
18.7K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
18.7K
02:57piRNA - Piwi-interacting RNAs
7.7K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.7K
02:04Covalently Linked Protein Regulators
9.7K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
These groups modify specific amino acids in a protein....
9.7K