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Related Experiment Videos

Radiosterilization of albuminated polyester prostheses.

C Baquey, M F Sigot-Luizard, J Friede

    Biomaterials
    |May 1, 1987
    PubMed
    Summary

    Radio-sterilization using gamma radiation is safe for albumin-coated Dacron vascular prostheses. This method preserves mechanical properties and shows no cytotoxicity, making it a suitable sterilization procedure.

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    Area of Science:

    • Biomaterials Science
    • Radiation Chemistry
    • Vascular Surgery

    Background:

    • Dacron vascular prostheses coated with crosslinked albumin are used in surgery.
    • Sterilization methods must preserve the integrity and function of these medical devices.
    • Radio-sterilization is a potential method for sterilizing albuminated Dacron prostheses.

    Purpose of the Study:

    • To evaluate the effects of gamma radiation on Dacron vascular prostheses coated with crosslinked albumin.
    • To assess the mechanical properties, crystallinity, and albumin leakage after radio-sterilization.
    • To determine the cytotoxicity of the radio-sterilized prostheses.

    Main Methods:

    • Gamma irradiation of Dacron vascular prostheses (dry and saline-immersed).
    • Assessment of mechanical properties and crystallinity of polyester fibers.
    • Use of 125I-labelled albumin to quantify albumin release.
    • Organotypic culture tests to evaluate cytotoxicity of the immersion medium.

    Main Results:

    • Gamma radiation did not affect the mechanical properties or crystallinity of Dacron fibers.
    • Albumin leakage was observed, but radioactivity measurements indicated radio-induced iodine-albumin bond breakage, not albumin-Dacron bond breakage.
    • No cytotoxicity was detected in the irradiated immersion medium.

    Conclusions:

    • Radio-sterilization of albuminated Dacron vascular prostheses immersed in saline is a suitable procedure.
    • The method preserves the essential properties of the prostheses.
    • Further studies on albumin leakage mechanisms are warranted.

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