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Updated: Feb 13, 2026

Virtual Prism Adaptation Therapy: Protocol for Validation in Healthy Adults
Published on: February 12, 2020
Frontal lesions predict response to prism adaptation treatment in spatial neglect: A randomised controlled study
Kelly M Goedert1, Peii Chen2,3, Anne L Foundas4
1Department of Psychology, Seton Hall University, South Orange, NJ, USA.
Prism adaptation treatment helps spatial neglect after stroke, but only for patients with frontal lobe lesions. Frontal lesions predict treatment response, aiding future clinical decisions for spatial neglect recovery.
Area of Science:
- Neuroscience
- Rehabilitation Medicine
- Clinical Neurology
Background:
- Spatial neglect is a common and disabling deficit following right hemisphere stroke.
- Prism adaptation (PA) shows promise for treating spatial neglect, but response varies.
- Previous research linked PA treatment benefits to frontal lobe lesions.
Purpose of the Study:
- To investigate whether frontal lobe lesions predict functional recovery in spatial neglect patients undergoing prism adaptation treatment.
- To compare PA treatment outcomes with standard care in a randomized controlled trial.
Main Methods:
- Randomized controlled trial design.
- Inclusion of individuals with spatial neglect.
- Intervention: 10 days of prism adaptation treatment versus standard care (control group).
- Assessment of functional improvement in neglect symptoms.
Main Results:
- Patients receiving prism adaptation treatment showed functional improvement only if they had frontal lobe lesions.
- In the control group, frontal lesions did not influence recovery.
- Replication of previous findings linking frontal lesions to PA treatment response.
Conclusions:
- Frontal lobe lesions appear to be a key predictor of response to prism adaptation treatment for spatial neglect.
- Further research is warranted to understand the role of frontal lesions in PA treatment efficacy.
- Findings may inform clinical decision-making regarding PA treatment for stroke survivors with spatial neglect.
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