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Updated: Feb 13, 2026

Activating Autophagy by Aerobic Exercise in Mice
Published on: February 3, 2017
Enterovirus Transmission by Secretory Autophagy
Yael Mutsafi1, Nihal Altan-Bonnet2
1Laboratory of Host-Pathogen Dynamics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. yael.mutsafibenhalevy@nih.gov.
Abstract:
Present in many cell types, non-degradative secretory autophagy is a newly discovered pathway in which autophagosomes fuse with the plasma membrane instead of lysosomes. Surprisingly, some viruses exploit secretory autophagy to exit cells non-lytically, shedding into the extracellular environment as particle populations contained within vesicles. As a result, this significantly enhances the infectivity of these viruses. In this paper, this novel cellular exit pathway is highlighted and its advantages for viral transmission discussed.
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