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Published on: October 24, 2015
The Roles of Protein Tyrosine Phosphatases in Hepatocellular Carcinoma
Yide Huang1,2, Yafei Zhang3, Lilin Ge4,5
1Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, College of Life Sciences, Fujian Normal University, Fuzhou 350117, China. ydhuang@fjnu.edu.cn.
Abstract:
The protein tyrosine phosphatase (PTP) family is involved in multiple cellular functions and plays an important role in various pathological and physiological processes. In many chronic diseases, for example cancer, PTP is a potential therapeutic target for cancer treatment. In the last two decades, dozens of PTP inhibitors which specifically target individual PTP molecules were developed as therapeutic agents. Hepatocellular carcinoma (HCC) is one of the most common malignant tumors and is the second most lethal cancer worldwide due to a lack of effective therapies. Recent studies have unveiled both oncogenic and tumor suppressive functions of PTP in HCC. Here, we review the current knowledge on the involvement of PTP in HCC and further discuss the possibility of targeting PTP in HCC.
Insights
Protein tyrosine phosphatases (PTPs) are key in cell functions and cancer. This review explores PTP roles in hepatocellular carcinoma (HCC) and discusses targeting PTPs for effective HCC therapy.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- Protein tyrosine phosphatases (PTPs) regulate crucial cellular functions.
- PTPs are implicated in various pathological and physiological processes, including cancer.
- PTPs represent a significant therapeutic target for numerous chronic diseases.
Purpose of the Study:
- To review the current understanding of PTP involvement in hepatocellular carcinoma (HCC).
- To discuss the potential of targeting PTPs as a therapeutic strategy for HCC.
- To highlight the dual oncogenic and tumor-suppressive roles of PTPs in HCC.
Main Methods:
- Literature review of studies on PTPs in HCC.
- Analysis of PTP inhibitor development and therapeutic potential.
- Synthesis of current knowledge on PTP functions in HCC pathogenesis.
Main Results:
- PTPs exhibit complex roles in HCC, acting as both oncogenes and tumor suppressors.
- Numerous PTP inhibitors have been developed, showing promise as therapeutic agents.
- Targeting specific PTPs may offer novel treatment avenues for HCC.
Conclusions:
- PTPs are critical players in HCC development and progression.
- Targeting PTPs holds significant therapeutic potential for hepatocellular carcinoma.
- Further research is warranted to elucidate specific PTP functions and optimize targeted therapies for HCC.
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