Related Experiment Video
Updated: Feb 13, 2026
09:21
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
12.7K
Cancer-associated ischemic stroke: A retrospective multicentre cohort study
Stefano Grazioli1, Maurizio Paciaroni2, Giancarlo Agnelli2
1Internal Medicine, Ospedale S.Antonio Abate, ASST Valle Olona, Gallarate, Italy.
Thrombosis Research
|March 21, 2018
Summary
Active cancer in ischemic stroke patients is linked to older age, venous thromboembolism, low LDL cholesterol, and cryptogenic stroke. These factors may indicate hypercoagulability as a cause for cancer-associated stroke.
Area of Science:
- Neurology
- Oncology
- Epidemiology
Background:
- The link between stroke and cancer requires further investigation.
- This study estimates the prevalence and outcomes of cancer-associated ischemic stroke.
Purpose of the Study:
- To estimate the prevalence of cancer-associated ischemic stroke.
- To describe clinical outcomes in these patients.
- To identify factors associated with active cancer.
Main Methods:
- Retrospective cohort study of adult ischemic stroke patients from two Italian hospitals (2005-2015).
- Collected clinical and laboratory data.
- Used multivariate logistic regression to find factors associated with active cancer.
Main Results:
- 4.4% of 2209 ischemic stroke patients had active cancer.
- Active cancer was associated with age >65, venous thromboembolism (VTE), low LDL cholesterol (<70 mg/dL), and cryptogenic stroke.
- Mortality was higher in cancer patients (21.5% vs. 10%).
Conclusions:
- Older age, VTE, low LDL, and cryptogenic stroke are independent predictors of active cancer in stroke patients.
- Findings suggest hypercoagulability may play a role in cancer-associated ischemic stroke.
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