Related Experiment Video

Updated: Feb 13, 2026

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
07:26

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

1.1K

A highlight on Sonic hedgehog pathway

Gabriela Basile Carballo1,2, Jéssica Ribeiro Honorato1,3,2, Giselle Pinto Farias de Lopes3

  • 1Laboratorio de Biomedicina do Cérebro, Instituto Estadual do Cérebro Paulo Niemeyer (IECPN), Secretaria de Estado de Saúde, Rua do Rezende 156, Centro, Rio de Janeiro, CEP: 20230-024, Brazil.

Cell Communication and Signaling : CCS
|March 22, 2018
PubMed

Insights

The Sonic hedgehog (Shh) signaling pathway is crucial in brain tumor development and resistance to cancer therapies. Understanding Shh signaling offers new therapeutic targets for brain cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Developmental Biology

Background:

  • The Hedgehog (Hh) signaling pathway is vital in embryonic development and cancer.
  • Sonic hedgehog (Shh) pathway activation contributes to radio- and chemo-resistance in various tumors.
  • Brain tumors often exhibit resistance to chemotherapy, leading to poor patient outcomes.

Purpose of the Study:

  • To explore the role of the Shh signaling pathway in brain tumorigenesis.
  • To identify potential therapeutic strategies targeting the Shh pathway for brain cancer treatment.
  • To review current clinical trials investigating Shh pathway inhibitors.

Main Methods:

  • Literature review of studies on Shh signaling in brain tumors.
  • Analysis of Shh pathway interactions with other signaling cascades.
  • Examination of data from ongoing clinical trials targeting Shh.

Main Results:

  • Shh signaling influences the development and drug resistance of brain tumors.
  • The pathway interacts with other molecular pathways implicated in tumorigenesis.
  • Several clinical trials are evaluating Shh inhibitors for brain cancer therapy.

Conclusions:

  • Targeting the Shh signaling pathway presents a promising therapeutic avenue for brain cancers.
  • A comprehensive understanding of Shh signaling mechanisms can lead to novel treatment strategies.
  • Further research and clinical trials are essential to fully exploit Shh pathway inhibitors.
Keywords:
Brain tumorsCanonical Shh signalingClinical-trialsNon-canonical Shh signalingSonic hedgehog pathway

More Related Videos

Direct Injection of a Lentiviral Vector Highlights Multiple Motor Pathways in the Rat Spinal Cord07:57

Direct Injection of a Lentiviral Vector Highlights Multiple Motor Pathways in the Rat Spinal Cord

Published on: March 15, 2019

9.2K
Photoconversion of Purified Fluorescent Proteins and Dual-probe Optical Highlighting in Live Cells11:21

Photoconversion of Purified Fluorescent Proteins and Dual-probe Optical Highlighting in Live Cells

Published on: June 26, 2010

12.5K

Related Concept Videos

Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
10.1K
C4 Pathway and CAM01:27

C4 Pathway and CAM

Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
49.3K
Other Glycolytic Pathways01:24

Other Glycolytic Pathways

The pentose phosphate pathway (PPP) operates in parallel with glycolysis, facilitating the metabolism of both pentoses and glucose. This pathway consists of two distinct phases: the oxidative and non-oxidative phases. While it does not directly generate ATP, the intermediates formed during the process can integrate into glycolysis, contributing to cellular energy metabolism when required.Oxidative Phase: NADPH ProductionThe oxidative phase of the pentose phosphate pathway is primarily...
993
Respiration Pathways01:26

Respiration Pathways

Cellular respiration is a fundamental metabolic process that enables organisms to generate energy from organic molecules. One of its central pathways is the tricarboxylic acid (TCA) cycle, also known as the Krebs cycle, which plays a crucial role in energy production and biosynthetic processes.Conversion of Pyruvate to Acetyl-CoAThe pyruvate generated from glycolysis undergoes oxidative decarboxylation by the pyruvate dehydrogenase complex, producing acetyl-CoA, one molecule of NADH, and one...
798
Auditory Pathway01:15

Auditory Pathway

Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
7.5K
ER Retrieval Pathway01:45

ER Retrieval Pathway

In the secretory pathway, vesicles transport proteins from one cellular compartment to another in forward transport to deliver the protein to its correct location. Occasionally, misfolded proteins and incorrect proteins escape their original compartments, and a retrieval pathway is used to return the escaped proteins to their original compartment.
The ER uses many checkpoints to prevent the entry of incorrectly folded or a resident protein as cargo onto a transport vesicle. These mechanisms...
4.9K