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Author Spotlight: Optimizing Bovine Lung Decellularization for Organotypic Hydrogels

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Published on: December 8, 2023

Matrix remodeling in chronic lung diseases.

Bon-Hee Gu¹, Matthew C Madison², David Corry³

¹Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.

Matrix Biology : Journal of the International Society for Matrix Biology

|March 22, 2018

Summary

Extracellular matrix molecules (ECMs) in the lung are vital for tissue structure and function. Changes in lung ECMs are linked to respiratory diseases like asthma, COPD, and IPF, offering potential therapeutic targets.

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Generation of Human 3D Lung Tissue Cultures 3D-LTCs for Disease Modeling

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Published on: February 12, 2019

Area of Science:

Pulmonary biology and extracellular matrix research.
Investigating the role of the lung extracellular matrix (ECM) in homeostasis and disease.

Background:

Multicellular organisms continuously synthesize and renew extracellular matrix molecules (ECMs) for structural and functional integrity.
Lung ECMs are crucial for maintaining tissue strength, elasticity, and guiding cell functions during development, repair, and homeostasis.
Aberrant ECM remodeling in the lung can expose cryptic fragments, contributing to chronic respiratory diseases.

Purpose of the Study:

To review how lung ECMs regulate homeostasis and cellular signaling.
To explore the pathological reorganization of lung ECMs in inflammatory lung diseases.
To highlight the potential of understanding ECM changes for novel therapeutic strategies in chronic lung diseases.

Main Methods:

This is a review article, synthesizing existing research on lung ECMs.
Literature review focusing on ECM structure, function, and alterations in disease.
Analysis of how ECM signaling impacts epithelial and mesenchymal cells in lung pathologies.

Main Results:

Lung ECMs play a critical role in maintaining tissue architecture and facilitating cellular processes like migration and proliferation.
Alterations in ECM composition and structure are associated with the pathogenesis of asthma, chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF).
ECMs actively relay signals to lung cells, influencing disease development and progression.

Conclusions:

Understanding the dynamic role of lung ECMs in homeostasis and disease is crucial.
Pathological changes in lung ECMs are implicated in common chronic respiratory diseases.
Targeting ECM remodeling pathways presents a promising avenue for developing new treatments for lung diseases.