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Updated: Feb 13, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
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A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

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Mean Platelet Volume as a Predictor for Restenosis After Carotid Angioplasty and Stenting

Zhengze Dai1, Jie Gao1, Shun Li1

  • 1From the Department of Neurology, Jinling Clinical College of Nanjing Medical University, China (Z.D., Z.C., X.L., G.X.); Department of Neurology, Nanjing Pukou Hospital, China (Z.D.); Department of Neurology, Jinling Hospital, Medical School of Nanjing University, China (J.G., R.L., X.L., G.X.); Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing, China (S.L.); Department of Neurology, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, China (Z.C.); and Department of Neurology, Jinling Hospital, Second Military Medical University, Nanjing, China (M.L.).

Stroke
|March 22, 2018
PubMed

Insights

Elevated mean platelet volume (MPV) is linked to in-stent restenosis (ISR) after carotid angioplasty and stenting (CAS). Patients with higher MPV before the procedure may need stronger antiplatelet treatment to prevent ISR.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Interventional Cardiology

Background:

  • Platelet aggregation is crucial in developing in-stent restenosis (ISR) post-carotid angioplasty and stenting (CAS).
  • Mean platelet volume (MPV) serves as an indicator of platelet reactivity.

Purpose of the Study:

  • To investigate the association between MPV and ISR in patients undergoing CAS.
  • To identify predictors of ISR after CAS.

Main Methods:

  • 261 patients with CAS were enrolled, with MPV measured pre-procedure.
  • ISR was assessed at 6 months and annually using angiography or ultrasonography.
  • Cox regression analysis identified predictors of ISR.

Main Results:

  • ISR occurred in 17.6% of patients over a mean follow-up of 12.1 months.
  • Elevated baseline MPV (>10.1 fL) was significantly associated with ISR (HR, 3.20).
  • Other predictors included lesion length, residual stenosis, and baseline glucose.

Conclusions:

  • Higher preprocedural MPV may indicate an increased risk of ISR after CAS.
  • Patients with elevated MPV might benefit from intensified antiplatelet therapy post-CAS.
Abstract

Keywords:
angioplastycarotid arteriesmean platelet volumeplatelet aggregationstroke

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