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Updated: Feb 13, 2026

Determining the Role of Maternally-Expressed Genes in Early Development with Maternal Crispants
Published on: December 21, 2021
Maternal Adverse Childhood Experiences and Infant Development.
Nicole Racine1,2, Andre Plamondon3, Sheri Madigan4,2
1Department of Psychology, Faculty of Arts, and.
Maternal adverse childhood experiences (ACEs) impact infant development through biological and psychosocial pathways. Interventions targeting maternal well-being during pregnancy are crucial for mitigating these effects.
Area of Science:
- Developmental Psychology
- Maternal Health
- Child Development
Background:
- Adverse Childhood Experiences (ACEs) in mothers can have lasting effects on offspring.
- Understanding the mechanisms linking maternal ACEs to child development is crucial for early intervention.
Purpose of the Study:
- To investigate prenatal and postnatal pathways through which maternal ACEs influence offspring's early development.
- To differentiate the roles of biological and psychosocial risks in this transmission.
Main Methods:
- Prospective longitudinal cohort study of 1994 mothers and infants.
- Data collected via questionnaires on psychosocial risk and infant behavior, and health records for biological risk.
- Infant development assessed at 12 months using the Ages and Stages Questionnaire.
Main Results:
- Maternal ACEs predicted infant development outcomes at 12 months via indirect pathways.
- Biological health risks (pregnancy and birth) and psychosocial risks (maternal stress and behavior) mediated the association.
- Psychosocial risks in pregnancy, but not infancy, were linked to maternal behavior transmission.
Conclusions:
- Maternal well-being during pregnancy is a critical factor in preventing the intergenerational transmission of risk.
- Targeting maternal health and psychosocial support during pregnancy may improve child development outcomes.
- Both biological and psychosocial pathways are important in understanding the impact of maternal ACEs on infant development.
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