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The relationship between hydration status, male sexual dysfunction and depression in hemodialysis patients

Kamal Hassan1,2, Yotam Elimeleh1, Mona Shehadeh3

  • 1Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel.

Therapeutics and Clinical Risk Management
|March 22, 2018
PubMed

Insights

Overhydration in hemodialysis patients is linked to increased sexual dysfunction and depression. This condition also correlates with lower testosterone and higher estradiol levels, impacting male health.

Area of Science:

  • Nephrology and Urology
  • Men's Health
  • Psychological Medicine

Background:

  • Sexual dysfunction and depression are prevalent issues for patients undergoing hemodialysis.
  • These conditions arise from a complex interplay of physiological, psychological, hormonal, neurological, and vascular factors.
  • This study investigated the association between overhydration and sexual dysfunction/depression in hemodialysis patients.

Purpose of the Study:

  • To examine the relationship between overhydration status and male sexual dysfunction.
  • To assess the correlation between overhydration and depression symptoms in hemodialysis patients.
  • To analyze the impact of overhydration on sex hormone levels in this population.

Main Methods:

  • A cross-sectional study involving 39 stable hemodialysis patients.
  • Hydration status was measured using whole-body bioimpedance spectroscopy, categorizing patients by their overhydration to extracellular water (OH/ECW) ratio.
  • Sexual function was assessed via the International Index of Erectile Function (IIEF) and psychological status using the Beck Depression Inventory (BDI). Serum sex hormones were also measured.

Main Results:

  • Overhydration (OH/ECW ratio >0.15) was present in 53.8% of patients.
  • Overhydrated patients exhibited significantly higher rates of erectile dysfunction (85.7%) and abnormal BDI scores (71.4%).
  • Overhydration correlated with lower IIEF scores, reduced total testosterone and DHEA, and elevated estradiol and hsCRP levels.

Conclusions:

  • Overhydration is significantly associated with a higher prevalence of sexual dysfunction and depression in hemodialysis patients.
  • The study found that overhydration relates to decreased levels of testosterone and dehydroepiandrosterone (DHEA) and increased estradiol.
  • Managing hydration status may be crucial for improving sexual function and psychological well-being in hemodialysis patients.
Abstract

Keywords:
Beck Depression Inventory scoreInternational Index of Erectile Function scoredepressionerectile dysfunctionhemodialysisoverhydrationsex hormones

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